Standard Name	MET2 1
Systematic Name	YNL277W
Feature Type	ORF, Verified
Description	L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway (2, 3)
Name Description	METhionine requiring 1

Chromosomal Location	ChrXIV:117349 to 118809 | ORF Map | GBrowse
	Genetic position: -187 cM

	View Computational GO annotations for MET2
Molecular Function
Manually curated	homoserine O-acetyltransferase activity (IDA, IMP)
Biological Process
Manually curated	homoserine metabolic process (IDA, IMP) methionine biosynthetic process (IMP) sulfur amino acid metabolic process (IMP)
Cellular Component
High-throughput	cytoplasm (IDA)

Pathways	homocysteine biosynthesis superpathway of methionine biosynthesis superpathway of sulfur amino acid biosynthesis superpathway of threonine and methionine biosynthesis

Classical genetics
null	auxotrophy metal resistance: increased
Large-scale survey
null	competitive fitness: increased starvation resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	10 total interaction(s) for 10 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Biochemical Activity: 5 Protein-RNA: 1 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 1 Synthetic Growth Defect: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:117349 to 118809 | ORF Map | GBrowse
	Genetic position: -187 cM
Last Update	Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1461 117349..118809 2005-11-07 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005221