SEC2/YNL272C Summary

SEC2 BASIC INFORMATION

Standard Name	SEC2 1, 2
Systematic Name	YNL272C
Feature Type	ORF, Verified
Description	Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles (3, 4)
Name Description	SECretory 1

GO Annotations	All SEC2 GO evidence and references
	View Computational GO annotations for SEC2
Molecular Function
Manually curated	guanyl-nucleotide exchange factor activity (IDA)
Biological Process
Manually curated	exocytosis (IMP)
Cellular Component
Manually curated	cytosol (IDA) transport vesicle (IDA)
High-throughput	mating projection tip (IDA)

Mutant Phenotype	All SEC2 Phenotype details and references
Classical genetics
conditional	endomembrane system morphology: abnormal invertase secretion: decreased invertase accumulation: increased
Large-scale survey
null	inviable
overexpression	filamentous growth: increased
repressible	mitochondrial morphology: abnormal

Interactions	SEC2 All interactions details and references
	154 total interaction(s) for 93 unique genes/features.
Physical Interactions	Affinity Capture-MS: 14 Affinity Capture-RNA: 1 Affinity Capture-Western: 6 Biochemical Activity: 31 Co-crystal Structure: 2 FRET: 1 Reconstituted Complex: 8 Two-hybrid: 13
Genetic Interactions	Dosage Growth Defect: 3 Dosage Lethality: 3 Dosage Rescue: 10 Synthetic Growth Defect: 4 Synthetic Lethality: 47 Synthetic Rescue: 11

Sequence Information

ChrXIV:129084 to 126805 | |

Note: this feature is encoded on the Crick strand.

Genetic position: -176 cM

Last Update

Coordinates: 2005-11-07 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2280	129084..126805	2005-11-07	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005216

SEC2 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for SEC2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SEC2]

1)	Novick P, et al. (1980) Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21(1):205-15
2)	Fields, C. and Schekman, R. (1985) Personal Communication, Mortimer Map Edition 9
3)	Walch-Solimena C, et al. (1997) Sec2p mediates nucleotide exchange on Sec4p and is involved in polarized delivery of post-Golgi vesicles. J Cell Biol 137(7):1495-509
4)	Medkova M, et al. (2006) The rab exchange factor Sec2p reversibly associates with the exocyst. Mol Biol Cell 17(6):2757-69

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