PDR17/YNL264C Summary Help

PDR17 BASIC INFORMATION

Standard Name PDR17 1
Systematic Name YNL264C
Alias ISS1 2 , SFH4
Feature Type ORF, Verified
Description Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition (1, 3, 4)
Name Description Pleiotropic Drug Resistance 5
GO Annotations All PDR17 GO evidence and references
    View Computational GO annotations for PDR17
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Mutant Phenotype All PDR17 Phenotype details and references
Classical genetics
overexpression
Large-scale survey
null
overexpression
Interactions PDR17 All interactions details and references
16 total interaction(s) for 13 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-Western: 1
  • Two-hybrid: 1
Genetic Interactions
  • Dosage Rescue: 5
  • Phenotypic Enhancement: 1
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 5
Sequence Information
ChrXIV:146616 to 145564 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1053 146616..145564 2005-11-07 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005208

PDR17 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for PDR17

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PDR17]

1) van den Hazel HB, et al.  (1999) PDR16 and PDR17, two homologous genes of Saccharomyces cerevisiae, affect lipid biosynthesis and resistance to multiple drugs. J Biol Chem 274(4):1934-41
2) Entian KD, et al.  (1999) Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach. Mol Gen Genet 262(4-5):683-702
3) Li X, et al.  (2000) Identification of a novel family of nonclassic yeast phosphatidylinositol transfer proteins whose function modulates phospholipase D activity and Sec14p-independent cell growth. Mol Biol Cell 11(6):1989-2005
4) Schnabl M, et al.  (2003) Subcellular localization of yeast Sec14 homologues and their involvement in regulation of phospholipid turnover. Eur J Biochem 270(15):3133-45
5) Wu WI, et al.  (2000) A new gene involved in the transport-dependent metabolism of phosphatidylserine, PSTB2/PDR17, shares sequence similarity with the gene encoding the phosphatidylinositol/phosphatidylcholine transfer protein, SEC14. J Biol Chem 275(19):14446-56