Standard Name	PDR17 1
Systematic Name	YNL264C
Alias	ISS1 2 , SFH4 3
Feature Type	ORF, Verified
Description	Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition (1, 3, 4)
Name Description	Pleiotropic Drug Resistance 1

Chromosomal Location	ChrXIV:146615 to 145563 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for PDR17
Molecular Function
Manually curated	NOT phosphatidylcholine transporter activity (IDA) phosphatidylinositol transporter activity (IDA, IGI, IMP)
Biological Process
Manually curated	Golgi to plasma membrane protein transport (IGI) negative regulation of phosphatidylglycerol biosynthetic process (IGI) phosphatidylserine metabolic process (IMP) phospholipid biosynthetic process (IGI) phospholipid transport (IDA, IGI, IMP) positive regulation of phosphatidylcholine biosynthetic process (IGI) response to drug (IGI) sterol biosynthetic process (IGI)
Cellular Component
Manually curated	cell periphery (IDA) cytosol (IDA) endosome (IDA)
High-throughput	cytoplasm (IDA)

Classical genetics
null	cold sensitivity: increased resistance to cadmium sulfate: decreased
overexpression	resistance to nocodazole: decreased
Large-scale survey
null	endocytosis: decreased haploinsufficient resistance to tirapazamine: increased resistance to benzo[a]pyrene: decreased stress resistance: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
overexpression	cell cycle progression: abnormal filamentous growth: increased resistance to sirolimus: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	52 total interaction(s) for 44 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-Western: 2 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 6 Negative Genetic: 28 Phenotypic Enhancement: 1 Synthetic Growth Defect: 4 Synthetic Lethality: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:146615 to 145563 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1053 146615..145563 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005208