RPA49/YNL248C Summary

RPA49 BASIC INFORMATION

Standard Name	RPA49 1
Systematic Name	YNL248C
Feature Type	ORF, Verified
Description	RNA polymerase I subunit A49 (1)
Name Description	RNA Polymerase A
Gene Product Alias	A49 2

GO Annotations	All RPA49 GO evidence and references
	View Computational GO annotations for RPA49
Molecular Function
Manually curated	DNA-directed RNA polymerase activity (TAS)
Biological Process
Manually curated	transcription of nuclear rRNA large RNA polymerase I transcript (IGI)
High-throughput	regulation of cell size (IMP)
Cellular Component
Manually curated	DNA-directed RNA polymerase I complex (IDA, IMP)

Mutant Phenotype	All RPA49 Phenotype details and references
Classical genetics
null	resistance to mycophenolic acid: decreased resistance to 6-azauracil: decreased utilization of carbon source: increased rate vegetative growth: decreased
Large-scale survey
null	bud morphology: abnormal competitive fitness: decreased fermentative growth: decreased rate resistance to caffeine: decreased resistance to hydroxyurea: decreased resistance to oleate: decreased resistance to mycophenolic acid: decreased resistance to 5-fluorouracil: decreased resistance to doxorubicin: decreased resistance to propan-1-ol: decreased sporulation: decreased toxin resistance: increased viable

Interactions	RPA49 All interactions details and references
	223 total interaction(s) for 146 unique genes/features.
Physical Interactions	Affinity Capture-MS: 68 Affinity Capture-Western: 4 Co-purification: 5 PCA: 2 Reconstituted Complex: 1 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 5 Phenotypic Enhancement: 52 Phenotypic Suppression: 46 Synthetic Growth Defect: 3 Synthetic Lethality: 34 Synthetic Rescue: 1

Sequence Information

ChrXIV:182609 to 181362 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2005-11-07 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1248	182609..181362	2005-11-07	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005192

RPA49 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for RPA49

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RPA49]

1)	Liljelund P, et al. (1992) Characterization and mutagenesis of the gene encoding the A49 subunit of RNA polymerase A in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 89(19):9302-5
2)	Riva M, et al. (1982) Natural variation in yeast RNA polymerase A. Formation of a mosaic RNA polymerase A in a meiotic segregant from an interspecific hybrid. J Biol Chem 257(8):4570-7

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