SUI1/YNL244C Summary Help

Standard Name SUI1 1
Systematic Name YNL244C
Alias MOF2 2 , RFR1
Feature Type ORF, Verified
Description Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase (2, 3, 4, 5)
Name Description SUppressor of Initiator codon 1
Chromosomal Location
ChrXIV:187496 to 187170 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: -171 cM
Gene Ontology Annotations All SUI1 GO evidence and references
  View Computational GO annotations for SUI1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Classical genetics
conditional
Large-scale survey
conditional
null
overexpression
reduction of function
Resources
138 total interaction(s) for 63 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 46
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 29
  • Co-crystal Structure: 1
  • Co-fractionation: 4
  • Co-purification: 1
  • PCA: 2
  • Reconstituted Complex: 19
  • Two-hybrid: 10

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Lethality: 1
  • Dosage Rescue: 6
  • Phenotypic Suppression: 3
  • Synthetic Lethality: 8
  • Synthetic Rescue: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 108
Molecular Weight (Da) 12,312
Isoelectric Point (pI) 8.1
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:187496 to 187170 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: -171 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..327 187496..187170 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005188
References cited on this page View Complete Literature Guide for SUI1
1) Donahue TF, et al.  (1988) Mutations at a Zn(II) finger motif in the yeast eIF-2 beta gene alter ribosomal start-site selection during the scanning process. Cell 54(5):621-32
2) Cui Y, et al.  (1998) The Mof2/Sui1 protein is a general monitor of translational accuracy. Mol Cell Biol 18(3):1506-16
3) Naranda T, et al.  (1996) SUI1/p16 is required for the activity of eukaryotic translation initiation factor 3 in Saccharomyces cerevisiae. Mol Cell Biol 16(5):2307-13
4) Yoon HJ and Donahue TF  (1992) The suil suppressor locus in Saccharomyces cerevisiae encodes a translation factor that functions during tRNA(iMet) recognition of the start codon. Mol Cell Biol 12(1):248-60
5) Harger JW and Dinman JD  (2004) Evidence against a direct role for the Upf proteins in frameshifting or nonsense codon readthrough. RNA 10(11):1721-9