SLA2/YNL243W Summary Help

SLA2 BASIC INFORMATION

Standard Name SLA2 1
Systematic Name YNL243W
Alias END4 2 , 3 , MOP2 4
Feature Type ORF, Verified
Description Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization; adaptor protein that links actin to clathrin and endocytosis; present in the actin cortical patch of the emerging bud tip; dimer in vivo (5, 6, 7, 8, 9)
Name Description Synthetic Lethal with ABP1 1
GO Annotations All SLA2 GO evidence and references
    View Computational GO annotations for SLA2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All SLA2 Phenotype details and references
Classical genetics
conditional
null
Large-scale survey
null
Interactions SLA2 All interactions details and references
127 total interaction(s) for 90 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 10
  • Affinity Capture-Western: 5
  • Co-fractionation: 3
  • Co-localization: 1
  • PCA: 11
  • Protein-peptide: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 22
Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 9
  • Phenotypic Suppression: 6
  • Synthetic Growth Defect: 13
  • Synthetic Lethality: 41
Sequence Information
ChrXIV:188052 to 190958 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2907 188052..190958 2005-11-07 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005187

SLA2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SLA2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SLA2]

1) Holtzman DA, et al.  (1993) Synthetic-lethal interactions identify two novel genes, SLA1 and SLA2, that control membrane cytoskeleton assembly in Saccharomyces cerevisiae. J Cell Biol 122(3):635-44
2) Wesp A, et al.  (1997) End4p/Sla2p interacts with actin-associated proteins for endocytosis in Saccharomyces cerevisiae. Mol Biol Cell 8(11):2291-306
3) Raths S, et al.  (1993) end3 and end4: two mutants defective in receptor-mediated and fluid-phase endocytosis in Saccharomyces cerevisiae. J Cell Biol 120(1):55-65
4) Na S, et al.  (1995) MOP2 (SLA2) affects the abundance of the plasma membrane H(+)-ATPase of Saccharomyces cerevisiae. J Biol Chem 270(12):6815-23
5) Pruyne D and Bretscher A  (2000) Polarization of cell growth in yeast. J Cell Sci 113 ( Pt 4):571-85
6) Yang S, et al.  (1999) Sla2p is associated with the yeast cortical actin cytoskeleton via redundant localization signals. Mol Biol Cell 10(7):2265-83
7) Munn AL  (2001) Molecular requirements for the internalisation step of endocytosis: insights from yeast. Biochim Biophys Acta 1535(3):236-57
8) Palecek J, et al.  (2001) Rpg1p/Tif32p, a subunit of translation initiation factor 3, interacts with actin-associated protein Sla2p. Biochem Biophys Res Commun 282(5):1244-50
9) Baggett JJ, et al.  (2003) The Sla2p talin domain plays a role in endocytosis in Saccharomyces cerevisiae. Genetics 165(4):1661-74