SIN4/YNL236W Summary Help

SIN4 BASIC INFORMATION

Standard Name SIN4 1, 2
Systematic Name YNL236W
Alias BEL2 , GAL22 , SDI3 3 , SSF5 , SSN4 , TSF3 3 , RYE1 , MED16 4
Feature Type ORF, Verified
Description Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription (5, 6)
Name Description Switch INdependent
GO Annotations All SIN4 GO evidence and references
    View Computational GO annotations for SIN4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All SIN4 Phenotype details and references
Classical genetics
null
unspecified
Large-scale survey
null
Interactions SIN4 All interactions details and references
234 total interaction(s) for 131 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 76
  • Affinity Capture-Western: 14
  • Co-purification: 9
  • Two-hybrid: 13
Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 4
  • Phenotypic Enhancement: 53
  • Phenotypic Suppression: 12
  • Synthetic Growth Defect: 19
  • Synthetic Lethality: 13
  • Synthetic Rescue: 20
Sequence Information
ChrXIV:206931 to 209855 | ORF Map | GBrowse
Gbrowse
Genetic position: -145 cM
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2925 206931..209855 2005-11-07 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005180

SIN4 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Protein Info & Structure
  • Localization Resources
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for SIN4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SIN4]

1) Jiang YW and Stillman DJ  (1992) Involvement of the SIN4 global transcriptional regulator in the chromatin structure of Saccharomyces cerevisiae. Mol Cell Biol 12(10):4503-14
2) Chen, S.  (1992) Personal Communication, Mortimer Map Edition 11
3) Stillman DJ, et al.  (1994) Epistasis analysis of suppressor mutations that allow HO expression in the absence of the yeast SW15 transcriptional activator. Genetics 136(3):781-8
4) Bourbon HM, et al.  (2004) A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell 14(5):553-7
5) Li Y, et al.  (1995) Yeast global transcriptional regulators Sin4 and Rgr1 are components of mediator complex/RNA polymerase II holoenzyme. Proc Natl Acad Sci U S A 92(24):10864-8
6) Myers LC and Kornberg RD  (2000) Mediator of transcriptional regulation. Annu Rev Biochem 69():729-49