Standard Name	PDR16 1
Systematic Name	YNL231C
Alias	SFH3 2
Feature Type	ORF, Verified
Description	Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress (1, 2, 3, 4)
Name Description	Pleiotropic Drug Resistance 1

Chromosomal Location	ChrXIV:217042 to 215987 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for PDR16
Molecular Function
Manually curated	NOT phosphatidylcholine transporter activity (IDA) phosphatidylinositol transporter activity (IDA, IGI, IMP)
Biological Process
Manually curated	phospholipid biosynthetic process (IGI) phospholipid transport (IDA, IGI, IMP) response to drug (IGI) sterol biosynthetic process (IGI)
Cellular Component
Manually curated	cell periphery (IDA) lipid particle (IDA)
High-throughput	cytoplasm (IDA) plasma membrane (IDA)

Classical genetics
null	cold sensitivity: increased resistance to miconazole: decreased resistance to nystatin: decreased resistance to ketoconazole: decreased resistance to Rhodamine-6-G: decreased resistance to Crystal Violet: decreased resistance to fluconazole: decreased viable
Large-scale survey
null	competitive fitness: normal competitive fitness: decreased resistance to fluconazole: decreased vacuolar morphology: abnormal viable
overexpression	filamentous growth: increased resistance to sirolimus: increased vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	27 total interaction(s) for 25 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-RNA: 3 Co-crystal Structure: 2 Co-purification: 1 Two-hybrid: 1
Genetic Interactions	Negative Genetic: 6 Phenotypic Enhancement: 2 Positive Genetic: 3 Synthetic Growth Defect: 5 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:217042 to 215987 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1056 217042..215987 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005175