CNM67/YNL225C Summary

CNM67 BASIC INFORMATION

Standard Name	CNM67 1
Systematic Name	YNL225C
Feature Type	ORF, Verified
Description	Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration (1, 2, 3)
Name Description	Chaotic Nuclear Migration 1

GO Annotations	All CNM67 GO evidence and references
	View Computational GO annotations for CNM67
Molecular Function
Manually curated	structural constituent of cytoskeleton (IPI)
Biological Process
Manually curated	microtubule nucleation (IPI) mitotic spindle organization (IMP)
Cellular Component
Manually curated	outer plaque of spindle pole body (IDA) spindle pole body (IDA)

Mutant Phenotype	All CNM67 Phenotype details and references
Classical genetics
null	cellular morphology: abnormal killer toxin resistance: decreased nuclear position: abnormal resistance to Echinocandin B: decreased sporulation: absent vegetative growth: decreased
overexpression	cell cycle progression in G2 phase: abnormal nuclear morphology: abnormal
Large-scale survey
null	UV resistance: decreased polyphosphate accumulation: abnormal competitive fitness: decreased fermentative growth: decreased rate inviable lipid particle morphology: abnormal resistance to rapamycin: decreased resistance to oxalic acid: decreased resistance to L-1,4-dithiothreitol: decreased resistance to tunicamycin: decreased sporulation: absent vegetative growth: absent viable
overexpression	vegetative growth: decreased

Interactions	CNM67 All interactions details and references
	46 total interaction(s) for 33 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-Western: 4 Biochemical Activity: 2 Co-purification: 1 FRET: 5 Two-hybrid: 13
Genetic Interactions	Phenotypic Enhancement: 2 Phenotypic Suppression: 1 Synthetic Growth Defect: 9 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 5

Sequence Information

ChrXIV:224470 to 222725 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2005-11-07 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1746	224470..222725	2005-11-07	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005169

CNM67 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for CNM67

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CNM67]

1)	Brachat A, et al. (1998) Saccharomyces cerevisiae cells with defective spindle pole body outer plaques accomplish nuclear migration via half-bridge-organized microtubules. Mol Biol Cell 9(5):977-91
2)	Hoepfner D, et al. (2000) Time-lapse video microscopy analysis reveals astral microtubule detachment in the yeast spindle pole mutant cnm67. Mol Biol Cell 11(4):1197-211
3)	Schaerer F, et al. (2001) Cnm67p is a spacer protein of the Saccharomyces cerevisiae spindle pole body outer plaque. Mol Biol Cell 12(8):2519-33

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