Standard Name	PSY2
Systematic Name	YNL201C
Feature Type	ORF, Verified
Description	Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3 (1, 2, 3, 4)
Name Description	Platinum SensitivitY 5

Chromosomal Location	ChrXIV:263203 to 260627 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for PSY2
Molecular Function
Manually curated	contributes_to protein serine/threonine phosphatase activity (IPI)
Biological Process
Manually curated	negative regulation of DNA damage checkpoint (IMP) protein dephosphorylation (IMP) response to DNA damage stimulus (IGI) signal transduction involved in meiotic recombination checkpoint (IMP)
Cellular Component
Manually curated	colocalizes_with condensed nuclear chromosome (IDA)
High-throughput	nucleus (IDA)

Classical genetics
null	meiotic recombination: decreased resistance to cisplatin: decreased resistance to oxaliplatin: decreased telomere length: abnormal
Large-scale survey
null	UV resistance: decreased competitive fitness: increased competitive fitness: decreased hyperosmotic stress resistance: decreased resistance to methyl methanesulfonate: decreased resistance to fenpropimorph: decreased resistance to caffeine: decreased resistance to cycloheximide: decreased resistance to bleomycin: decreased resistance to quinine: decreased resistance to sodium arsenite: decreased resistance to arsenite(3-): decreased resistance to tunicamycin: increased resistance to hydroxyurea: increased resistance to sodium selenide: decreased resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyrimidine: decreased resistance to elesclomol-Cu: decreased starvation resistance: decreased stress resistance: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	155 total interaction(s) for 98 unique genes/features.
Physical Interactions	Affinity Capture-MS: 54 Affinity Capture-RNA: 2 Affinity Capture-Western: 4 Biochemical Activity: 2 Protein-RNA: 1 Reconstituted Complex: 1 Two-hybrid: 13
Genetic Interactions	Negative Genetic: 49 Phenotypic Enhancement: 3 Phenotypic Suppression: 4 Positive Genetic: 11 Synthetic Growth Defect: 8 Synthetic Lethality: 1 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:263203 to 260627 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2577 263203..260627 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005145