Standard Name	CHS1
Systematic Name	YNL192W
Alias	USA4 1
Feature Type	ORF, Verified
Description	Chitin synthase I, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor (2, 3, 4)
Name Description	CHitin Synthase

Chromosomal Location	ChrXIV:276502 to 279897 | ORF Map | GBrowse

	View Computational GO annotations for CHS1
Molecular Function
Manually curated	chitin synthase activity (IDA)
Biological Process
Manually curated	cytokinesis, completion of separation (IMP)
Cellular Component
Manually curated	chitosome (IDA) plasma membrane (IDA)
High-throughput	integral to membrane (ISM)

Pathways	chitin biosynthesis

Classical genetics
null	trypan blue accumulation: normal trypan blue accumulation: increased resistance to polyoxin D: decreased viable
Large-scale survey
null	chitin deposition: increased competitive fitness: decreased haploinsufficient resistance to cycloheximide: decreased resistance to gentamycin C1: decreased resistance to sodium arsenite: decreased resistance to quinine: decreased resistance to Calcofluor White: normal resistance to PM02734: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	178 total interaction(s) for 123 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8 Affinity Capture-RNA: 3 Biochemical Activity: 4 Co-fractionation: 2 PCA: 2 Reconstituted Complex: 1
Genetic Interactions	Negative Genetic: 23 Phenotypic Suppression: 1 Positive Genetic: 16 Synthetic Growth Defect: 34 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 82 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:276502 to 279897 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3396 276502..279897 2011-02-03 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005136