Standard Name	SRP1 (see Nomenclature conflict Note)
Systematic Name	YNL189W
Alias	KAP60 , SCM1
Feature Type	ORF, Verified
Description	Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation (1, 2)
Name Description	Suppressor of rpb1

Chromosomal Location	ChrXIV:284260 to 285888 | ORF Map | GBrowse

	View Computational GO annotations for SRP1
Molecular Function
Manually curated	protein transporter activity (IDA)
Biological Process
Manually curated	protein import into nucleus (IMP) protein targeting to membrane (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) colocalizes_with nuclear exosome (RNase complex) (IDA) nucleus (IDA)
High-throughput	integral to membrane (ISM) nucleus (IDA)

Classical genetics
conditional	cell cycle progression through the G1/S phase transition: abnormal cold sensitivity: increased heat sensitivity: increased nuclear import: decreased nuclear import: normal resistance to benomyl: decreased resistance to hydroxyurea: decreased resistance to benomyl: normal
unspecified	actin cytoskeleton morphology: abnormal endocytosis: decreased
Large-scale survey
conditional	heat sensitivity: increased
null	filamentous growth: decreased haploproficient invasive growth: absent inviable nutrient utilization: increased resistance to elesclomol-Cu: decreased toxin resistance: decreased
overexpression	vegetative growth: decreased rate
reduction of function	competitive fitness: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	410 total interaction(s) for 237 unique genes/features.
Physical Interactions	Affinity Capture-MS: 190 Affinity Capture-RNA: 2 Affinity Capture-Western: 32 Biochemical Activity: 5 Co-crystal Structure: 1 Co-localization: 1 Co-purification: 3 PCA: 2 Protein-peptide: 2 Reconstituted Complex: 35 Two-hybrid: 84
Genetic Interactions	Dosage Rescue: 5 Negative Genetic: 28 Phenotypic Enhancement: 2 Phenotypic Suppression: 2 Positive Genetic: 2 Synthetic Growth Defect: 4 Synthetic Lethality: 9 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:284260 to 285888 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1629 284260..285888 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005133