Standard Name	UBP10 1
Systematic Name	YNL186W
Alias	DOT4 2
Feature Type	ORF, Verified
Description	Ubiquitin-specific protease, deubiquitinates Ub-protein moieties; interacts with proteins that function in rRNA production and ribosome biogenesis; stabilizes Rpa190p, the largest subunit of RNAP I, by mediating its deubiquitination; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; localized to the nucleolus; human USP36 is a functional analog of Ubp10p (2, 3, 4, 5)
Name Description	UBiquitin-specific Protease 1

Chromosomal Location	ChrXIV:289498 to 291876 | ORF Map | GBrowse

	View Computational GO annotations for UBP10
Molecular Function
Manually curated	ubiquitin-specific protease activity (IDA)
Biological Process
Manually curated	chromatin silencing at telomere (IMP) protein deubiquitination (IDA, IMP, TAS)
Cellular Component
Manually curated	nucleus (IDA)
High-throughput	nucleus (IDA)

Classical genetics
null	cold sensitivity: increased heat sensitivity: increased resistance to canavanine sulfate: decreased silencing: decreased
overexpression	budding index: abnormal silencing: decreased vegetative growth: decreased
Large-scale survey
overexpression	silencing: decreased vegetative growth: decreased rate vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	181 total interaction(s) for 152 unique genes/features.
Physical Interactions	Affinity Capture-MS: 102 Affinity Capture-RNA: 2 Affinity Capture-Western: 6 Biochemical Activity: 28 PCA: 14 Protein-peptide: 4 Reconstituted Complex: 3 Two-hybrid: 5
Genetic Interactions	Dosage Lethality: 2 Dosage Rescue: 1 Phenotypic Enhancement: 3 Phenotypic Suppression: 2 Synthetic Growth Defect: 4 Synthetic Rescue: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:289498 to 291876 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2379 289498..291876 2011-02-03 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005130