Standard Name	IPI3 1
Systematic Name	YNL182C
Feature Type	ORF, Verified
Description	Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene (1, 2, 3)
Name Description	Involved in Processing ITS2 1

Chromosomal Location	ChrXIV:297627 to 295960 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for IPI3
Molecular Function
Manually curated	chromatin binding (IDA)
Biological Process
Manually curated	pre-replicative complex assembly (IMP) regulation of DNA-dependent DNA replication initiation (IMP) ribosomal large subunit assembly (IMP) rRNA processing (IMP)
Cellular Component
Manually curated	nucleoplasm (IDA) pre-replicative complex (IDA) Rix1 complex (IDA)
High-throughput	nucleus (IDA)

Classical genetics
conditional	chromosome/plasmid maintenance: abnormal
null	dessication resistance: increased
repressible	mature 25S rRNA accumulation: decreased 35S pre-rRNA accumulation: increased 7S pre-rRNA accumulation: increased 27S pre-rRNA accumulation: increased 20S pre-rRNA accumulation: decreased mature 18S rRNA accumulation: decreased cell cycle progression in G1 phase: arrested
Large-scale survey
null	inviable starvation resistance: decreased
reduction of function	competitive fitness: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	115 total interaction(s) for 55 unique genes/features.
Physical Interactions	Affinity Capture-MS: 64 Affinity Capture-Western: 13 Biochemical Activity: 4 Co-fractionation: 3 Co-purification: 2 PCA: 2 Two-hybrid: 27
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:297627 to 295960 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1668 297627..295960 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005126