APC1/YNL172W Summary

APC1 BASIC INFORMATION

Standard Name	APC1
Systematic Name	YNL172W
Feature Type	ORF, Verified
Description	Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition (1, 2, 3)
Name Description	Anaphase Promoting Complex subunit

GO Annotations	All APC1 GO evidence and references
	View Computational GO annotations for APC1
Molecular Function
Manually curated	protein binding (TAS) ubiquitin-protein ligase activity (TAS)
Biological Process
Manually curated	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (IDA, IPI) cyclin catabolic process (TAS) mitotic metaphase/anaphase transition (TAS) mitotic sister chromatid segregation (TAS) mitotic spindle elongation (TAS) protein ubiquitination (IPI)
Cellular Component
Manually curated	anaphase-promoting complex (IDA)

Mutant Phenotype	All APC1 Phenotype details and references
Large-scale survey
null	inviable

Interactions	APC1 All interactions details and references
	91 total interaction(s) for 41 unique genes/features.
Physical Interactions	Affinity Capture-MS: 49 Affinity Capture-Western: 11 Biochemical Activity: 1 Co-fractionation: 3 Two-hybrid: 14
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 1 Synthetic Growth Defect: 5 Synthetic Lethality: 6

Sequence Information

ChrXIV:310638 to 315884 | |

Last Update

Coordinates: 2005-11-07 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..5247	310638..315884	2005-11-07	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005116

APC1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for APC1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for APC1]

1)	Zachariae W, et al. (1996) Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae. Science 274(5290):1201-4
2)	Zachariae W, et al. (1998) Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science 279(5354):1216-9
3)	Zachariae W and Nasmyth K (1999) Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 13(16):2039-58

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