SKO1/YNL167C Summary Help

SKO1 BASIC INFORMATION

Standard Name SKO1 1
Systematic Name YNL167C
Alias ACR1 2
Feature Type ORF, Verified
Description Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, forms a complex with Tup1p and Ssn6p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses (1, 3, 4, 5, 6, 7)
Name Description Suppressor of PKA Overexpression
GO Annotations All SKO1 GO evidence and references
    View Computational GO annotations for SKO1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulatory Role
Binding motifs SKO1 Transcription Factor Binding Sites and References
  • TGACGTCA
Regulatory modules predicted: stressResponse ( 571 , 493 )
Mutant Phenotype All SKO1 Phenotype details and references
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Interactions SKO1 All interactions details and references
34 total interaction(s) for 26 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 7
  • Biochemical Activity: 6
  • PCA: 1
  • Reconstituted Complex: 1
Genetic Interactions
  • Dosage Rescue: 2
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 8
  • Synthetic Growth Defect: 1
  • Synthetic Rescue: 3
Sequence Information
ChrXIV:321361 to 319418 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: -110 cM
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1944 321361..319418 2005-11-07 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005111

SKO1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SKO1

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
SFC1Nomenclature conflict"ACR1" has been used as an alias for three different genes:YPR199C/ARR1 (a YAP1-like transcriptional regulator), YNL167C/SKO1 (a CREB like trancsriptional repressor), and YJR095W/SFC1 (a succinate-fumarate transport protein).
ARR1Nomenclature conflict"ACR1" has been used as an alias for three different genes:YPR199C/ARR1 (a YAP1-like transcriptional regulator), YNL167C/SKO1 (a CREB like trancsriptional repressor), and YJR095W/SFC1 (a succinate-fumarate transport protein).

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SKO1]

1) Nehlin JO, et al.  (1992) Yeast SKO1 gene encodes a bZIP protein that binds to the CRE motif and acts as a repressor of transcription. Nucleic Acids Res 20(20):5271-8
2) Vincent AC and Struhl K  (1992) ACR1, a yeast ATF/CREB repressor. Mol Cell Biol 12(12):5394-405
3) Rep M, et al.  (2001) The Saccharomyces cerevisiae Sko1p transcription factor mediates HOG pathway-dependent osmotic regulation of a set of genes encoding enzymes implicated in protection from oxidative damage. Mol Microbiol 40(5):1067-83
4) Serrano R and Rodriguez-Navarro A  (2001) Ion homeostasis during salt stress in plants. Curr Opin Cell Biol 13(4):399-404
5) Pascual-Ahuir A, et al.  (2001) Multiple levels of control regulate the yeast cAMP-response element-binding protein repressor Sko1p in response to stress. J Biol Chem 276(40):37373-8
6) Proft M and Struhl K  (2002) Hog1 kinase converts the Sko1-Cyc8-Tup1 repressor complex into an activator that recruits SAGA and SWI/SNF in response to osmotic stress. Mol Cell 9(6):1307-17
7) Tomas-Cobos L, et al.  (2004) Expression of the HXT1 low affinity glucose transporter requires the coordinated activities of the HOG and glucose signalling pathways. J Biol Chem 279(21):22010-9