Standard Name	SKO1 1 (see Nomenclature conflict Note)
Systematic Name	YNL167C
Alias	ACR1 2
Feature Type	ORF, Verified
Description	Basic leucine zipper transcription factor of the ATF/CREB family; forms a complex with Tup1p and Cyc8p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses (1, 3, 4, 5, 6, 7)
Name Description	Suppressor of Kinase Overexpression 1

Chromosomal Location	ChrXIV:321359 to 319416 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -110 cM

	View Computational GO annotations for SKO1
Molecular Function
Manually curated	mitogen-activated protein kinase binding (IDA, IMP) RNA polymerase II core promoter proximal region sequence-specific DNA binding (IDA, IMP) RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription (IDA, IMP) RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (IDA, IMP) RNA polymerase II repressing transcription factor binding (IDA) RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription (IGI, IMP) sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity (IMP)
Biological Process
Manually curated	negative regulation of transcription from RNA polymerase II promoter (IMP) positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress (IDA, IGI, IMP)
Cellular Component
Manually curated	cytosol (IDA) nucleus (IDA)

Binding motifs	Predicted SKO1 Binding Site Locations
	TGACGTCA 1 [Search intergenic regions for TGACGTCA]
Regulatory modules	predicted: stressResponse (571, 493)
Resources	ScerTF | YEASTRACT | YeTFaSCo

Classical genetics
null	cell cycle progression in G1 phase: normal cell shape: normal resistance to quinine: decreased resistance to caffeine: decreased resistance to sirolimus: decreased
overexpression	cell shape: abnormal hyperosmotic stress resistance: decreased FUS1-GFP distribution: abnormal vegetative growth: absent
Large-scale survey
null	competitive fitness: decreased haploproficient resistance to ethanol: decreased resistance to PM02734: increased resistance to fluconazole: decreased resistance to fenpropimorph: decreased resistance to L-canavanine: increased resistance to mycophenolic acid: decreased resistance to caffeine: decreased resistance to bleomycin: decreased vacuolar morphology: abnormal viable
overexpression	cell cycle progression in G1 phase: abnormal vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	62 total interaction(s) for 47 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8 Affinity Capture-RNA: 1 Affinity Capture-Western: 8 Biochemical Activity: 6 Co-localization: 1 PCA: 3 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 11 Phenotypic Enhancement: 2 Phenotypic Suppression: 8 Positive Genetic: 4 Synthetic Growth Defect: 2 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:321359 to 319416 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -110 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1944 321359..319416 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005111