AAH1/YNL141W Summary Help

Standard Name AAH1 1
Systematic Name YNL141W
Feature Type ORF, Verified
Description Adenine deaminase (adenine aminohydrolase); converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome (1, 2, 3)
Name Description Adenine AminoHydrolase 1
Chromosomal Location
ChrXIV:359596 to 360639 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All AAH1 GO evidence and references
  View Computational GO annotations for AAH1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 2 genes
Resources
Pathways
Classical genetics
null
Large-scale survey
null
overexpression
unspecified
Resources
152 total interaction(s) for 142 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 9
  • Affinity Capture-RNA: 1
  • PCA: 2

Genetic Interactions
  • Negative Genetic: 107
  • Phenotypic Enhancement: 2
  • Positive Genetic: 22
  • Synthetic Growth Defect: 6
  • Synthetic Lethality: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 347
Molecular Weight (Da) 39,635
Isoelectric Point (pI) 5.15
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:359596 to 360639 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1044 359596..360639 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005085
References cited on this page View Complete Literature Guide for AAH1
1) Woods RA, et al.  (1984) Adenine phosphoribosyltransferase mutants in Saccharomyces cerevisiae. J Gen Microbiol 130(10):2629-37
2) Guetsova ML, et al.  (1997) The isolation and characterization of Saccharomyces cerevisiae mutants that constitutively express purine biosynthetic genes. Genetics 147(2):383-97
3) Escusa S, et al.  (2006) Proteasome- and SCF-dependent degradation of yeast adenine deaminase upon transition from proliferation to quiescence requires a new F-box protein named Saf1p. Mol Microbiol 60(4):1014-25