Standard Name	SRV2 1
Systematic Name	YNL138W
Alias	CAP
Feature Type	ORF, Verified
Description	CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis (1, 2, 3)
Name Description	Suppressor of RasVal19 1

Chromosomal Location	ChrXIV:366741 to 368321 | ORF Map | GBrowse
	Genetic position: -101 cM

	View Computational GO annotations for SRV2
Molecular Function
Manually curated	adenylate cyclase binding (TAS) cytoskeletal protein binding (TAS)
Biological Process
Manually curated	cytoskeleton organization (TAS) Ras protein signal transduction (IMP)
Cellular Component
Manually curated	actin cortical patch (IDA)
High-throughput	mating projection tip (IDA)

Classical genetics
conditional	heat sensitivity: increased
null	budding pattern: abnormal cell shape: abnormal filamentous growth: abnormal inviable
unspecified	pseudohyphal growth: absent
Large-scale survey
conditional	colony sectoring: increased
null	bud morphology: abnormal cell size: increased chitin deposition: normal competitive fitness: decreased haploproficient heat sensitivity: increased hyperosmotic stress resistance: decreased lipid particle morphology: abnormal metal resistance: increased oxidative stress resistance: decreased resistance to lovastatin: decreased resistance to benomyl: decreased resistance to cycloheximide: decreased resistance to paromomycin: decreased resistance to neomycin: decreased resistance to methanol: decreased resistance to ethanol: decreased resistance to (S)-lactic acid: decreased resistance to acetic acid: decreased resistance to propan-1-ol: decreased resistance to mycophenolic acid: decreased resistance to sodium arsenite: decreased resistance to hydrogen chloride: decreased resistance to 5-fluorouracil: decreased respiratory growth: absent sporulation: decreased starvation resistance: decreased transposable element transposition: increased vegetative growth: decreased rate viable
overexpression	filamentous growth: increased vegetative growth: decreased rate
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	113 total interaction(s) for 66 unique genes/features.
Physical Interactions	Affinity Capture-MS: 36 Affinity Capture-RNA: 2 Affinity Capture-Western: 6 Co-fractionation: 3 PCA: 13 Protein-peptide: 2 Reconstituted Complex: 7 Two-hybrid: 15
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 2 Negative Genetic: 3 Phenotypic Enhancement: 3 Phenotypic Suppression: 3 Synthetic Growth Defect: 3 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 11 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:366741 to 368321 | ORF Map | GBrowse
	Genetic position: -101 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1581 366741..368321 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005082