SPC98/YNL126W Summary Help

Standard Name SPC98
Systematic Name YNL126W
Feature Type ORF, Verified
Description Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque (1, 2)
Name Description Spindle Pole Component
Chromosomal Location
ChrXIV:387227 to 389767 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SPC98 GO evidence and references
  View Computational GO annotations for SPC98
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
conditional
overexpression
Large-scale survey
conditional
null
overexpression
Resources
83 total interaction(s) for 22 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 17
  • Affinity Capture-Western: 15
  • Co-localization: 1
  • Co-purification: 4
  • FRET: 3
  • Reconstituted Complex: 4
  • Two-hybrid: 12

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Rescue: 10
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 2
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 7
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 846
Molecular Weight (Da) 98,226
Isoelectric Point (pI) 7.5
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:387227 to 389767 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2541 387227..389767 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005070
References cited on this page View Complete Literature Guide for SPC98
1) Nguyen T, et al.  (1998) A genetic analysis of interactions with Spc110p reveals distinct functions of Spc97p and Spc98p, components of the yeast gamma-tubulin complex. Mol Biol Cell 9(8):2201-16
2) Knop M, et al.  (1997) The spindle pole body component Spc97p interacts with the gamma-tubulin of Saccharomyces cerevisiae and functions in microtubule organization and spindle pole body duplication. EMBO J 16(7):1550-64