Standard Name	SPC98
Systematic Name	YNL126W
Feature Type	ORF, Verified
Description	Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque (1, 2)
Name Description	Spindle Pole Component

Chromosomal Location	ChrXIV:387227 to 389767 | ORF Map | GBrowse

	View Computational GO annotations for SPC98
Molecular Function
Manually curated	structural constituent of cytoskeleton (IPI)
Biological Process
Manually curated	microtubule nucleation (IPI) mitotic spindle organization in nucleus (IMP)
Cellular Component
Manually curated	gamma-tubulin small complex, spindle pole body (IPI) inner plaque of spindle pole body (IDA) outer plaque of spindle pole body (IDA)

Classical genetics
conditional	colony sectoring: increased
overexpression	budding index: abnormal cell cycle progression in G2 phase: abnormal cell size: increased
Large-scale survey
conditional	chromosome/plasmid maintenance: abnormal heat sensitivity: increased redox state: abnormal
null	cell size: increased competitive fitness: decreased haploinsufficient heat sensitivity: increased inviable toxin resistance: decreased
overexpression	cell cycle progression: abnormal vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	81 total interaction(s) for 22 unique genes/features.
Physical Interactions	Affinity Capture-MS: 17 Affinity Capture-Western: 15 Co-localization: 1 Co-purification: 4 FRET: 3 Reconstituted Complex: 4 Two-hybrid: 12
Genetic Interactions	Dosage Growth Defect: 2 Dosage Rescue: 10 Phenotypic Suppression: 1 Synthetic Growth Defect: 4 Synthetic Lethality: 7 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:387227 to 389767 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2541 387227..389767 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005070