SPC98/YNL126W Summary

SPC98 BASIC INFORMATION

Standard Name	SPC98
Systematic Name	YNL126W
Feature Type	ORF, Verified
Description	Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque (1, 2)
Name Description	Spindle Pole Component

GO Annotations	All SPC98 GO evidence and references
	View Computational GO annotations for SPC98
Molecular Function
Manually curated	structural constituent of cytoskeleton (IPI)
Biological Process
Manually curated	microtubule nucleation (IPI) mitotic spindle organization in nucleus (IMP)
Cellular Component
Manually curated	gamma-tubulin small complex, spindle pole body (IPI) inner plaque of spindle pole body (IDA) outer plaque of spindle pole body (IDA)

Mutant Phenotype	All SPC98 Phenotype details and references
Classical genetics
overexpression	budding index: abnormal cell cycle progression in G2 phase: abnormal cell size: increased
Large-scale survey
conditional	heat sensitivity: increased
null	competitive fitness: decreased haploinsufficient inviable
overexpression	vegetative growth: decreased

Interactions	SPC98 All interactions details and references
	72 total interaction(s) for 19 unique genes/features.
Physical Interactions	Affinity Capture-MS: 15 Affinity Capture-Western: 13 Co-purification: 4 FRET: 3 Reconstituted Complex: 3 Two-hybrid: 12
Genetic Interactions	Dosage Rescue: 11 Synthetic Growth Defect: 3 Synthetic Lethality: 8

Sequence Information

ChrXIV:387229 to 389769 | |

Last Update

Coordinates: 2005-11-07 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2541	387229..389769	2005-11-07	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005070

SPC98 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for SPC98

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SPC98]

1)	Nguyen T, et al. (1998) A genetic analysis of interactions with Spc110p reveals distinct functions of Spc97p and Spc98p, components of the yeast gamma-tubulin complex. Mol Biol Cell 9(8):2201-16
2)	Knop M, et al. (1997) The spindle pole body component Spc97p interacts with the gamma-tubulin of Saccharomyces cerevisiae and functions in microtubule organization and spindle pole body duplication. EMBO J 16(7):1550-64

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