DCP2/YNL118C Summary Help

DCP2 BASIC INFORMATION

Standard Name DCP2
Systematic Name YNL118C
Alias PSU1
Feature Type ORF, Verified
Description Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family (1, 2, 3)
Name Description mRNA DeCaPping 4
GO Annotations All DCP2 GO evidence and references
    View Computational GO annotations for DCP2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All DCP2 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions DCP2 All interactions details and references
109 total interaction(s) for 66 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 26
  • Affinity Capture-RNA: 5
  • Affinity Capture-Western: 6
  • Biochemical Activity: 1
  • Co-purification: 1
  • PCA: 10
  • Reconstituted Complex: 4
  • Two-hybrid: 42
Genetic Interactions
  • Dosage Rescue: 3
  • Phenotypic Enhancement: 6
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 3
Sequence Information
ChrXIV:405566 to 402654 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2913 405566..402654 2005-11-07 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005062

DCP2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Localization Resources
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for DCP2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for DCP2]

1) Gaudon C, et al.  (1999) Role of the essential yeast protein PSU1 in p6anscriptional enhancement by the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J 18(8):2229-40
2) Dunckley T, et al.  (2001) Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae. Genetics 157(1):27-37
3) She M, et al.  (2006) Crystal structure and functional analysis of Dcp2p from Schizosaccharomyces pombe. Nat Struct Mol Biol 13(1):63-70
4) Dunckley T and Parker R  (1999) The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif. EMBO J 18(19):5411-22