Standard Name	YAF9
Systematic Name	YNL107W
Feature Type	ORF, Verified
Description	Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain (1, 2)
Name Description	Yeast homolog of the human leukemogenic protein AF9 2

Chromosomal Location	ChrXIV:420098 to 420778 | ORF Map | GBrowse

	View Computational GO annotations for YAF9
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	chromatin remodeling (IDA, IPI) chromatin silencing at telomere (IMP) DNA repair (IDA) histone exchange (IMP)
High-throughput	chromatin remodeling (IGI)
Cellular Component
Manually curated	NuA4 histone acetyltransferase complex (IPI) Swr1 complex (IDA)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Classical genetics
null	UV resistance: decreased inositol excretion: increased chromosome/plasmid maintenance: abnormal osmotic stress resistance: decreased prion formation: decreased resistance to methyl methanesulfonate: decreased resistance to benomyl: decreased resistance to hydroxyurea: decreased resistance to sirolimus: decreased resistance to geneticin: decreased
Large-scale survey
null	UV resistance: decreased anaerobic growth: decreased bud morphology: abnormal glycogen accumulation: increased inositol excretion: increased competitive fitness: decreased dessication resistance: decreased haploinsufficient heat sensitivity: increased metal resistance: decreased oxidative stress resistance: decreased protein transport: abnormal resistance to (S)-lactic acid: increased resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to sirolimus: decreased resistance to oleate: decreased resistance to ethanol: decreased resistance to CTBT: decreased resistance to propolis extract: decreased resistance to pyrrolidine dithiocarbamate: decreased resistance to methyl methanesulfonate: decreased resistance to hygromycin B: decreased resistance to spermine: decreased resistance to sodium selenide: decreased resistance to flubendazole: decreased resistance to wortmannin: normal resistance to lovastatin: decreased resistance to arsenite(3-): decreased resistance to caffeine: decreased resistance to benzo[a]pyrene: decreased resistance to doxorubicin: decreased sporulation efficiency: increased toxin resistance: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	688 total interaction(s) for 379 unique genes/features.
Physical Interactions	Affinity Capture-MS: 89 Affinity Capture-RNA: 1 Affinity Capture-Western: 36 Co-crystal Structure: 2 Two-hybrid: 58
Genetic Interactions	Dosage Growth Defect: 11 Dosage Rescue: 2 Negative Genetic: 231 Phenotypic Enhancement: 7 Positive Genetic: 37 Synthetic Growth Defect: 149 Synthetic Lethality: 56 Synthetic Rescue: 9
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:420098 to 420778 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..681 420098..420778 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005051