Standard Name	OCA1
Systematic Name	YNL099C
Feature Type	ORF, Verified
Description	Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA (1, 2)
Name Description	Oxidant-induced Cell-cycle Arrest 1

Chromosomal Location	ChrXIV:439283 to 438567 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for OCA1
Molecular Function
Manually curated	protein tyrosine phosphatase activity (ISS)
Biological Process
Manually curated	cellular response to oxidative stress (IMP)
Cellular Component
High-throughput	cytoplasm (IDA)

Classical genetics
null	resistance to caffeine: decreased resistance to 13-hydroperoxylinoleic acid: decreased
Large-scale survey
null	glycogen accumulation: decreased competitive fitness: decreased haploinsufficient heat sensitivity: increased oxidative stress resistance: decreased resistance to methyl methanesulfonate: decreased resistance to sodium arsenite: decreased resistance to caffeine: decreased resistance to wortmannin: decreased resistance to sirolimus: decreased resistance to bleomycin: increased resistance to nickel sulfate: increased resistance to cycloheximide: decreased resistance to fenpropimorph: decreased resistance to hydroxyurea: decreased resistance to tunicamycin: decreased resistance to dimethyl sulfoxide: decreased resistance to elesclomol-Cu: decreased resistance to benzo[a]pyrene: decreased toxin resistance: decreased transposable element transposition: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	146 total interaction(s) for 122 unique genes/features.
Physical Interactions	Affinity Capture-MS: 15 Affinity Capture-RNA: 4 Reconstituted Complex: 1 Two-hybrid: 6
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 1 Negative Genetic: 76 Positive Genetic: 37 Synthetic Growth Defect: 2 Synthetic Lethality: 1 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:439283 to 438567 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..717 439283..438567 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005043