PHO23/YNL097C Summary

PHO23 BASIC INFORMATION

Standard Name	PHO23
Systematic Name	YNL097C
Feature Type	ORF, Verified
Description	Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3 (1, 2, 3, 4)
Name Description	PHOsphate metabolism

GO Annotations	All PHO23 GO evidence and references
	View Computational GO annotations for PHO23
Molecular Function
Manually curated	histone deacetylase activity (IDA) methylated histone residue binding (IDA)
Biological Process
Manually curated	chromatin modification (IMP, IPI, ISS) histone deacetylation (IDA)
Cellular Component
Manually curated	histone deacetylase complex (IDA) Rpd3L complex (IDA)
High-throughput	nucleus (IDA) Rpd3L complex (IDA) Rpd3L-Expanded complex (IDA)

Mutant Phenotype	All PHO23 Phenotype details and references
Classical genetics
null	inositols excretion: increased GFP-Rap1 distribution: abnormal resistance to cycloheximide: decreased resistance to camptothecin: decreased viable
Large-scale survey
null	inositols excretion: increased competitive fitness: decreased filamentous growth: decreased invasive growth: absent resistance to wortmannin: decreased resistance to rapamycin: increased resistance to calcium dichloride: decreased resistance to cycloheximide: decreased resistance to sulfanilamide: decreased resistance to doxorubicin: decreased respiratory growth: decreased rate viable
overexpression	vegetative growth: decreased

Interactions	PHO23 All interactions details and references
	378 total interaction(s) for 220 unique genes/features.
Physical Interactions	Affinity Capture-Luminescence: 4 Affinity Capture-MS: 51 Affinity Capture-Western: 10 Biochemical Activity: 2 Two-hybrid: 3
Genetic Interactions	Phenotypic Enhancement: 159 Phenotypic Suppression: 51 Synthetic Growth Defect: 60 Synthetic Lethality: 33 Synthetic Rescue: 5

Sequence Information

ChrXIV:442360 to 441368 | |

Note: this feature is encoded on the Crick strand.

This feature contains embedded feature(s): YNL097W-A

Last Update

Coordinates: 2005-11-07 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..993	442360..441368	2005-11-07	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005041

PHO23 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for PHO23

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PHO23]

1)	Lau WW, et al. (1998) A genetic study of signaling processes for repression of PHO5 transcription in Saccharomyces cerevisiae. Genetics 150(4):1349-59
2)	Loewith R, et al. (2000) Three yeast proteins related to the human candidate tumor suppressor p33(ING1) are associated with histone acetyltransferase activities. Mol Cell Biol 20(11):3807-16
3)	Loewith R, et al. (2001) Pho23 is associated with the Rpd3 histone deacetylase and is required for its normal function in regulation of gene expression and silencing in Saccharomyces cerevisiae. J Biol Chem 276(26):24068-74
4)	Gordon PM, et al. (2008) Interspecies data mining to predict novel ING-protein interactions in human. BMC Genomics 9:426

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