APP1/YNL094W Summary Help

Standard Name APP1 1
Systematic Name YNL094W
Feature Type ORF, Verified
Description Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway (1, 2, 3)
Name Description Actin Patch Protein 1
Chromosomal Location
ChrXIV:447611 to 449374 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All APP1 GO evidence and references
  View Computational GO annotations for APP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Large-scale survey
null
overexpression
unspecified
Resources
86 total interaction(s) for 57 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 10
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Biochemical Activity: 4
  • Protein-peptide: 2
  • Two-hybrid: 41

Genetic Interactions
  • Negative Genetic: 21
  • Positive Genetic: 3
  • Synthetic Growth Defect: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 587
Molecular Weight (Da) 66,134
Isoelectric Point (pI) 6.11
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:447611 to 449374 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1764 447611..449374 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005038
References cited on this page View Complete Literature Guide for APP1
1) Samanta MP and Liang S  (2003) Predicting protein functions from redundancies in large-scale protein interaction networks. Proc Natl Acad Sci U S A 100(22):12579-83
2) Bon E, et al.  (2000) A network of proteins around Rvs167p and Rvs161p, two proteins related to the yeast actin cytoskeleton. Yeast 16(13):1229-41
3) Chae M, et al.  (2012) The Saccharomyces cerevisiae actin patch protein App1p is a phosphatidate phosphatase enzyme. J Biol Chem 287(48):40186-96