RHO2/YNL090W Summary Help

Standard Name RHO2 1
Systematic Name YNL090W
Feature Type ORF, Verified
Description Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly (2 and see Summary Paragraph)
Name Description Ras HOmolog 1
Chromosomal Location
ChrXIV:456565 to 457143 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All RHO2 GO evidence and references
  View Computational GO annotations for RHO2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulatory Role
Regulatory modules predicted: stressResponse (385)
Mutant phenotypes All RHO2 Phenotype evidence and references
Classical genetics
null
Large-scale survey
null
Resources
interactions All RHO2 Interaction evidence and references
141 total interaction(s) for 114 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 7
Genetic Interactions
  • Dosage Rescue: 26
  • Negative Genetic: 87
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 9
  • Synthetic Growth Defect: 3
Resources
Expression Summary
histogram
Resources
Protein Information All RHO2 Protein evidence and references
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:456565 to 457143 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..579 456565..457143 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005034
SUMMARY PARAGRAPH for RHO2

RHO2 encodes a non-essential small GTPase in the Rho/Rac subfamily of Ras-like GTPases (1). Other S. cerevisiae Rho GTPases are encoded by RHO1, RHO3, RHO4, RHO5, and CDC42 (2). Rho2p may play a role in the establishment of cell polarity or in microtubule assembly (2). Deletion of RHO2 causes increased sensitivity to the microtubule depolymerizing drug benomyl (3). Overexpression of RHO2 suppresses the temperature sensitivity of cik1 or kar3 deletions; CIK1 and KAR3 encode microtubule-associated proteins (3). The GTPase activity of Rho2p is positively regulated by the GTPase activating protein (GAP) Bem2p, and negatively regulated by the guanine nucleotide exchange factors (GEFs) Rom1p and Rom2p (2).

Last updated: 1999-11-24

References cited on this page View Complete Literature Guide for RHO2
1) Madaule P, et al.  (1987) Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 84(3):779-83
2) Madden K and Snyder M  (1998) Cell polarity and morphogenesis in budding yeast. Annu Rev Microbiol 52():687-744
3) Manning BD, et al.  (1997) The Rho-GEF Rom2p localizes to sites of polarized cell growth and participates in cytoskeletal functions in Saccharomyces cerevisiae. Mol Biol Cell 8(10):1829-44