END3/YNL084C Summary Help

END3 BASIC INFORMATION

Standard Name END3 1, 2
Systematic Name YNL084C
Feature Type ORF, Verified
Description EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p (3, 4)
Name Description ENDocytosis defective 2
GO Annotations All END3 GO evidence and references
    View Computational GO annotations for END3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All END3 Phenotype details and references
Classical genetics
conditional
null
Large-scale survey
null
Interactions END3 All interactions details and references
95 total interaction(s) for 64 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 9
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 7
  • PCA: 4
  • Reconstituted Complex: 1
  • Two-hybrid: 18
Genetic Interactions
  • Dosage Rescue: 5
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 3
  • Synthetic Growth Defect: 18
  • Synthetic Lethality: 23
  • Synthetic Rescue: 3
Sequence Information
ChrXIV:471104 to 470055 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1050 471104..470055 2005-11-07 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005028

END3 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for END3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for END3]

1) Benedetti H, et al.  (1994) The END3 gene encodes a protein that is required for the internalization step of endocytosis and for actin cytoskeleton organization in yeast. Mol Biol Cell 5(9):1023-37
2) Chvatchko Y, et al.  (1986) Two yeast mutants defective in endocytosis are defective in pheromone response. Cell 46(3):355-64
3) Tang HY, et al.  (1997) EH domain proteins Pan1p and End3p are components of a complex that plays a dual role in organization of the cortical actin cytoskeleton and endocytosis in Saccharomyces cerevisiae. Mol Cell Biol 17(8):4294-304
4) Tang HY, et al.  (2000) Pan1p, End3p, and S1a1p, three yeast proteins required for normal cortical actin cytoskeleton organization, associate with each other and play essential roles in cell wall morphogenesis. Mol Cell Biol 20(1):12-25