END3/YNL084C Summary Help

Standard Name END3 1, 2
Systematic Name YNL084C
Feature Type ORF, Verified
Description EH domain-containing protein involved in endocytosis; actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p (3, 4)
Name Description ENDocytosis defective 2
Chromosomal Location
ChrXIV:471102 to 470053 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All END3 GO evidence and references
  View Computational GO annotations for END3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
conditional
null
Large-scale survey
null
Resources
244 total interaction(s) for 179 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 15
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 7
  • Co-localization: 1
  • PCA: 10
  • Reconstituted Complex: 1
  • Two-hybrid: 119

Genetic Interactions
  • Dosage Rescue: 5
  • Negative Genetic: 14
  • Phenotypic Enhancement: 9
  • Phenotypic Suppression: 6
  • Positive Genetic: 6
  • Synthetic Growth Defect: 21
  • Synthetic Lethality: 24
  • Synthetic Rescue: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 349
Molecular Weight (Da) 40,297
Isoelectric Point (pI) 5.08
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:471102 to 470053 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1050 471102..470053 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005028
References cited on this page View Complete Literature Guide for END3
1) Benedetti H, et al.  (1994) The END3 gene encodes a protein that is required for the internalization step of endocytosis and for actin cytoskeleton organization in yeast. Mol Biol Cell 5(9):1023-37
2) Chvatchko Y, et al.  (1986) Two yeast mutants defective in endocytosis are defective in pheromone response. Cell 46(3):355-64
3) Tang HY, et al.  (1997) EH domain proteins Pan1p and End3p are components of a complex that plays a dual role in organization of the cortical actin cytoskeleton and endocytosis in Saccharomyces cerevisiae. Mol Cell Biol 17(8):4294-304
4) Tang HY, et al.  (2000) Pan1p, End3p, and S1a1p, three yeast proteins required for normal cortical actin cytoskeleton organization, associate with each other and play essential roles in cell wall morphogenesis. Mol Cell Biol 20(1):12-25