Standard Name	TPM1
Systematic Name	YNL079C
Feature Type	ORF, Verified
Description	Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	TroPoMyosin
Gene Product Alias	tropomyosin

Chromosomal Location	ChrXIV:479165 to 478566 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for TPM1
Molecular Function
Manually curated	actin lateral binding (TAS)
Biological Process
Manually curated	actin filament bundle assembly (IGI) actin filament organization (TAS) actin polymerization or depolymerization (TAS) budding cell apical bud growth (TAS) budding cell isotropic bud growth (TAS) establishment of cell polarity (TAS) exocytosis (TAS) filamentous growth (IMP) intracellular mRNA localization (TAS) mitochondrion inheritance (TAS) pseudohyphal growth (IMP) vacuole inheritance (TAS) vesicle-mediated transport (TAS)
Cellular Component
Manually curated	actin filament bundle (IDA) cellular bud neck contractile ring (IDA)

Classical genetics
null	Ptr2p-GFP distribution: abnormal
unspecified	pseudohyphal growth: absent
Large-scale survey
null	auxotrophy bud morphology: abnormal glycogen accumulation: increased chitin deposition: increased competitive fitness: decreased dessication resistance: decreased endocytosis: decreased fermentative growth: decreased rate heat sensitivity: increased mitochondrial genome maintenance: abnormal nutrient utilization: increased resistance to cycloheximide: decreased resistance to bleomycin: increased resistance to fluconazole: increased resistance to hydroxyurea: increased resistance to methyl methanesulfonate: increased resistance to tunicamycin: increased resistance to sirolimus: decreased resistance to Calcofluor White: decreased resistance to ethanol: decreased resistance to propan-1-ol: decreased resistance to mefloquine: decreased resistance to wortmannin: normal resistance to camptothecin: increased resistance to sorbate: decreased respiratory growth: decreased rate stress resistance: increased toxin resistance: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	271 total interaction(s) for 200 unique genes/features.
Physical Interactions	Affinity Capture-MS: 15 Affinity Capture-RNA: 5 Affinity Capture-Western: 1 Co-purification: 1 Reconstituted Complex: 2 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 6 Negative Genetic: 166 Phenotypic Enhancement: 9 Phenotypic Suppression: 9 Positive Genetic: 9 Synthetic Growth Defect: 12 Synthetic Lethality: 27 Synthetic Rescue: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:479165 to 478566 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..600 479165..478566 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005023