MKS1/YNL076W Summary Help

Standard Name MKS1 1
Systematic Name YNL076W
Alias LYS80
Feature Type ORF, Verified
Description Pleiotropic negative transcriptional regulator; involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling (1, 2, 3, 4)
Name Description Multicopy Kinase Suppressor 1
Chromosomal Location
ChrXIV:483556 to 485310 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MKS1 GO evidence and references
  View Computational GO annotations for MKS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Resources
Classical genetics
null
overexpression
unspecified
Large-scale survey
null
overexpression
unspecified
Resources
172 total interaction(s) for 144 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 19
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 12
  • Reconstituted Complex: 2

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 1
  • Negative Genetic: 100
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 3
  • Positive Genetic: 9
  • Synthetic Growth Defect: 7
  • Synthetic Lethality: 4
  • Synthetic Rescue: 12

Resources
Expression Summary
histogram
Resources
Length (a.a.) 584
Molecular Weight (Da) 65,642
Isoelectric Point (pI) 10.14
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:483556 to 485310 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1755 483556..485310 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005020
References cited on this page View Complete Literature Guide for MKS1
1) Matsuura A and Anraku Y  (1993) Characterization of the MKS1 gene, a new negative regulator of the Ras-cyclic AMP pathway in Saccharomyces cerevisiae. Mol Gen Genet 238(1-2):6-16
2) Edskes HK, et al.  (1999) Mks1p is a regulator of nitrogen catabolism upstream of Ure2p in Saccharomyces cerevisiae. Genetics 153(2):585-94
3) Feller A, et al.  (1997) Lys80p of Saccharomyces cerevisiae, previously proposed as a specific repressor of LYS genes, is a pleiotropic regulatory factor identical to Mks1p. Yeast 13(14):1337-46
4) Sekito T, et al.  (2002) RTG-dependent mitochondria-to-nucleus signaling is regulated by MKS1 and is linked to formation of yeast prion [URE3]. Mol Biol Cell 13(3):795-804