NOP2/YNL061W Summary Help

NOP2 BASIC INFORMATION

Standard Name NOP2
Systematic Name YNL061W
Alias YNA1
Feature Type ORF, Verified
Description Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles (1, 2, 3, 4)
Name Description NucleOlar Protein 1
GO Annotations All NOP2 GO evidence and references
    View Computational GO annotations for NOP2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All NOP2 Phenotype details and references
Large-scale survey
null
repressible
Interactions NOP2 All interactions details and references
185 total interaction(s) for 84 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 180
  • Affinity Capture-Western: 2
Genetic Interactions
  • Synthetic Lethality: 3
Sequence Information
ChrXIV:510542 to 512398 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2010-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1857 510542..512398 2010-01-05 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005005

NOP2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for NOP2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for NOP2]

1) de Beus E, et al.  (1994) Yeast NOP2 encodes an essential nucleolar protein with homology to a human proliferation marker. J Cell Biol 127(6 Pt 2):1799-813
2) King M, et al.  (1999) A conserved motif in the yeast nucleolar protein Nop2p contains an essential cysteine residue. Biochem J 337 ( Pt 1)():29-35
3) Hong B, et al.  (2001) Temperature sensitive nop2 alleles defective in synthesis of 25S rRNA and large ribosomal subunits in Saccharomyces cerevisiae. Nucleic Acids Res 29(14):2927-37
4) Horsey EW, et al.  (2004) Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation. RNA 10(5):813-27