VAC7/YNL054W Summary Help

Standard Name VAC7 1
Systematic Name YNL054W
Feature Type ORF, Verified
Description Integral vacuolar membrane protein; involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock (1, 2, 3)
Name Description VACuolar segregation
Chromosomal Location
ChrXIV:526086 to 529583 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All VAC7 GO evidence and references
  View Computational GO annotations for VAC7
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
misexpression
null
Large-scale survey
null
overexpression
Resources
43 total interaction(s) for 41 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 1
  • Biochemical Activity: 1
  • PCA: 1
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 1
  • Positive Genetic: 2
  • Synthetic Growth Defect: 22
  • Synthetic Lethality: 4
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,165
Molecular Weight (Da) 128,139
Isoelectric Point (pI) 5.87
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:526086 to 529583 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3498 526086..529583 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004999
References cited on this page View Complete Literature Guide for VAC7
1) Bonangelino CJ, et al.  (1997) Vac7p, a novel vacuolar protein, is required for normal vacuole inheritance and morphology. Mol Cell Biol 17(12):6847-58
2) Gary JD, et al.  (2002) Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member. Mol Biol Cell 13(4):1238-51
3) Duex JE, et al.  (2006) The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover. J Cell Biol 172(5):693-704