IDH1/YNL037C Summary Help

Standard Name IDH1 1
Systematic Name YNL037C
Feature Type ORF, Verified
Description Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; complex catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle (2)
Name Description Isocitrate DeHydrogenase 1
Chromosomal Location
ChrXIV:559002 to 557920 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All IDH1 GO evidence and references
  View Computational GO annotations for IDH1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 12 genes
Resources
Pathways
Classical genetics
null
reduction of function
unspecified
Large-scale survey
null
Resources
213 total interaction(s) for 136 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 22
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Co-crystal Structure: 2
  • Co-purification: 1
  • PCA: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 132
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 4
  • Positive Genetic: 28
  • Synthetic Growth Defect: 6
  • Synthetic Lethality: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 360
Molecular Weight (Da) 39,324
Isoelectric Point (pI) 9.81
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:559002 to 557920 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1083 559002..557920 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004982
References cited on this page View Complete Literature Guide for IDH1
1) Cupp JR and McAlister-Henn L  (1991) NAD(+)-dependent isocitrate dehydrogenase. Cloning, nucleotide sequence, and disruption of the IDH2 gene from Saccharomyces cerevisiae. J Biol Chem 266(33):22199-205
2) Cupp JR and McAlister-Henn L  (1992) Cloning and characterization of the gene encoding the IDH1 subunit of NAD(+)-dependent isocitrate dehydrogenase from Saccharomyces cerevisiae. J Biol Chem 267(23):16417-23