Standard Name	SIW14 1
Systematic Name	YNL032W
Alias	OCA3 2
Feature Type	ORF, Verified
Description	Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm (3, 4, 5)
Name Description	Synthetic Interaction with Whi2 1

Chromosomal Location	ChrXIV:574506 to 575351 | ORF Map | GBrowse

	View Computational GO annotations for SIW14
Molecular Function
Manually curated	protein tyrosine phosphatase activity (ISS)
Biological Process
Manually curated	actin filament organization (IMP) endocytosis (IMP) protein dephosphorylation (ISS) response to stress (IGI)
Cellular Component
High-throughput	cytoplasm (IDA)

Regulatory modules	predicted: cellcycle (347)

Classical genetics
null	endocytosis: decreased metal resistance: increased resistance to caffeine: decreased resistance to 13-hydroperoxylinoleic acid: decreased resistance to hygromycin B: decreased viable
Large-scale survey
null	competitive fitness: decreased haploproficient resistance to L-canavanine: increased resistance to methyl methanesulfonate: decreased resistance to L-1,4-dithiothreitol: decreased resistance to caffeine: decreased resistance to tunicamycin: decreased resistance to nickel sulfate: increased resistance to mycophenolic acid: decreased resistance to hydroxyurea: decreased resistance to fluconazole: decreased resistance to cycloheximide: decreased resistance to camptothecin: decreased resistance to bleomycin: decreased resistance to acetic acid: decreased telomere length: decreased transposable element transposition: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	140 total interaction(s) for 114 unique genes/features.
Physical Interactions	Affinity Capture-MS: 16 Affinity Capture-RNA: 3 Two-hybrid: 7
Genetic Interactions	Dosage Growth Defect: 2 Dosage Lethality: 1 Dosage Rescue: 4 Negative Genetic: 70 Phenotypic Enhancement: 1 Phenotypic Suppression: 2 Positive Genetic: 25 Synthetic Growth Defect: 3 Synthetic Lethality: 4 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:574506 to 575351 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..846 574506..575351 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004977