SSN8/YNL025C Summary Help

SSN8 BASIC INFORMATION

Standard Name SSN8 1, 2
Systematic Name YNL025C
Alias GIG3 3 , NUT9 , SRB11 4 , UME3 , RYE2
Feature Type ORF, Verified
Description Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance (3, 4, 5, 6)
Also known as: CycC 7
Name Description Suppressor of SNf1 1
GO Annotations All SSN8 GO evidence and references
    View Computational GO annotations for SSN8
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All SSN8 Phenotype details and references
Classical genetics
null
unspecified
Large-scale survey
null
Interactions SSN8 All interactions details and references
215 total interaction(s) for 177 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 10
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 16
  • Biochemical Activity: 1
  • Co-purification: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 22
Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 3
  • Phenotypic Enhancement: 49
  • Phenotypic Suppression: 75
  • Synthetic Growth Defect: 19
  • Synthetic Lethality: 11
  • Synthetic Rescue: 4
Sequence Information
ChrXIV:585293 to 584322 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2010-01-05 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..972 585293..584322 2010-01-05 1997-01-28
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004970

SSN8 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for SSN8

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SSN8]

1) Carlson M, et al.  (1984) A suppressor of SNF1 mutations causes constitutive high-level invertase synthesis in yeast. Genetics 107(1):19-32
2) Smith, J.B., et al.,  (1995) UME3 {ssn8}, a new C-type cyclin involved in the developmental switch between meiotic and mitotic cell division in S. cerevisiae. Unpublished
3) Balciunas D and Ronne H  (1995) Three subunits of the RNA polymerase II mediator complex are involved in glucose repression. Nucleic Acids Res 23(21):4421-5
4) Liao SM, et al.  (1995) A kinase-cyclin pair in the RNA polymerase II holoenzyme. Nature 374(6518):193-6
5) Kuchin S, et al.  (1995) Cyclin-dependent protein kinase and cyclin homologs SSN3 and SSN8 contribute to transcriptional control in yeast. Proc Natl Acad Sci U S A 92(9):4006-10
6) Askree SH, et al.  (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63
7) Bourbon HM, et al.  (2004) A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell 14(5):553-7