HRB1/YNL004W Summary Help

Standard Name HRB1
Systematic Name YNL004W
Alias TOM34
Feature Type ORF, Verified
Description Poly(A+) RNA-binding protein; key surveillance factor for the selective export of spliced mRNAs from the nucleus to the cytoplasm; preference for intron-containing genes; similar to Npl3p; HRB1 has a paralog, GBP2, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Hypothetical RNA-Binding protein
Chromosomal Location
ChrXIV:622915 to 624621 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HRB1 GO evidence and references
  View Computational GO annotations for HRB1
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Large-scale survey
null
Resources
97 total interaction(s) for 64 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 54
  • Affinity Capture-RNA: 7
  • Affinity Capture-Western: 2
  • Biochemical Activity: 2
  • Co-localization: 1

Genetic Interactions
  • Negative Genetic: 12
  • Phenotypic Enhancement: 1
  • Positive Genetic: 15
  • Synthetic Growth Defect: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 454
Molecular Weight (Da) 52,141
Isoelectric Point (pI) 7.61
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:622915 to 624621 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2007-07-09
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..30 622915..622944 2011-02-03 2007-07-09
Intron 31..372 622945..623286 2011-02-03 2007-07-09
CDS 373..1707 623287..624621 2011-02-03 2007-07-09
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004949
References cited on this page View Complete Literature Guide for HRB1
1) Hacker S and Krebber H  (2004) Differential export requirements for shuttling serine/arginine-type mRNA-binding proteins. J Biol Chem 279(7):5049-52
2) Hurt E, et al.  (2004) Cotranscriptional recruitment of the serine-arginine-rich (SR)-like proteins Gbp2 and Hrb1 to nascent mRNA via the TREX complex. Proc Natl Acad Sci U S A 101(7):1858-62
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Hackmann A, et al.  (2014) Quality control of spliced mRNAs requires the shuttling SR proteins Gbp2 and Hrb1. Nat Commun 5():3123