Standard Name	HRB1
Systematic Name	YNL004W
Alias	TOM34
Feature Type	ORF, Verified
Description	Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; HRB1 has a paralog, GBP2, that arose from the whole genome duplication (1, 2, 3)
Name Description	Hypothetical RNA-Binding protein

Chromosomal Location	ChrXIV:622915 to 624621 | ORF Map | GBrowse

	View Computational GO annotations for HRB1
Molecular Function
Manually curated	RNA binding (IDA)
Biological Process
Manually curated	poly(A)+ mRNA export from nucleus (IPI)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA)
High-throughput	integral to membrane (ISM)

Large-scale survey
null	competitive fitness: increased endocytosis: decreased hyperosmotic stress resistance: decreased resistance to glycolaldehyde: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	93 total interaction(s) for 62 unique genes/features.
Physical Interactions	Affinity Capture-MS: 52 Affinity Capture-RNA: 7 Affinity Capture-Western: 2 Biochemical Activity: 2
Genetic Interactions	Negative Genetic: 12 Phenotypic Enhancement: 1 Positive Genetic: 14 Synthetic Growth Defect: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:622915 to 624621 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2007-07-09
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..30 622915..622944 2011-02-03 2007-07-09 Intron 31..372 622945..623286 2011-02-03 2007-07-09 CDS 373..1707 623287..624621 2011-02-03 2007-07-09
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS) Intron (31 - 372)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004949