Standard Name	DOM34 1
Systematic Name	YNL001W
Feature Type	ORF, Verified
Description	Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication (2, 3, 4, 5, 6, 7, 8, 9)
Name Description	Duplication Of Multilocus region 3

Chromosomal Location	ChrXIV:627456 to 628616 | ORF Map | GBrowse

	View Computational GO annotations for DOM34
Molecular Function
Manually curated	NOT endoribonuclease activity (IDA) endoribonuclease activity (IDA) contributes_to ribosome binding (IDA)
Biological Process
Manually curated	nonfunctional rRNA decay (IMP) nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay (IDA) nuclear-transcribed mRNA catabolic process, no-go decay (IGI, IMP) ribosome disassembly (IDA)
Cellular Component
High-throughput	cytoplasm (IDA)

Classical genetics
null	cell cycle progression in G1 phase: delayed growth in exponential phase: decreased rate meiosis: abnormal pseudohyphal growth: decreased sporulation efficiency: decreased
Large-scale survey
null	competitive fitness: decreased dessication resistance: decreased haploinsufficient ionic stress resistance: decreased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to ethanol: decreased resistance to methyl methanesulfonate: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	100 total interaction(s) for 76 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 2 Affinity Capture-Western: 2 Biochemical Activity: 4 Co-crystal Structure: 5 Co-fractionation: 1 Co-purification: 1 Reconstituted Complex: 2 Two-hybrid: 2
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 1 Negative Genetic: 30 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 3 Synthetic Growth Defect: 36 Synthetic Lethality: 1 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:627456 to 628616 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1161 627456..628616 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004946