TGL3/YMR313C Summary Help

Standard Name TGL3 1
Systematic Name YMR313C
Feature Type ORF, Verified
Description Bifunctional triacylglycerol lipase and LPE acyltransferase; major lipid particle-localized triacylglycerol (TAG) lipase; catalyzes acylation of lysophosphatidylethanolamine (LPE), a function which is essential for sporulation; protein level and stability of Tgl3p are markedly reduced in the absence of lipid droplets; required with Tgl4p for timely bud formation (1, 2, 3, 4)
Name Description TriacylGlycerol Lipase 1
Chromosomal Location
ChrXIII:901307 to 899379 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All TGL3 GO evidence and references
  View Computational GO annotations for TGL3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
52 total interaction(s) for 40 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Biochemical Activity: 1
  • Co-fractionation: 1
  • PCA: 4
  • Protein-peptide: 1
  • Two-hybrid: 3

Genetic Interactions
  • Negative Genetic: 15
  • Phenotypic Enhancement: 3
  • Positive Genetic: 19
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 642
Molecular Weight (Da) 73,612
Isoelectric Point (pI) 8.5
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:901307 to 899379 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1929 901307..899379 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004930
References cited on this page View Complete Literature Guide for TGL3
1) Athenstaedt K and Daum G  (2003) YMR313c/TGL3 encodes a novel triacylglycerol lipase located in lipid particles of Saccharomyces cerevisiae. J Biol Chem 278(26):23317-23
2) Kurat CF, et al.  (2009) Cdk1/Cdc28-dependent activation of the major triacylglycerol lipase Tgl4 in yeast links lipolysis to cell-cycle progression. Mol Cell 33(1):53-63
3) Rajakumari S and Daum G  (2010) Janus-faced Enzymes Yeast Tgl3p and Tgl5p Catalyze Lipase and Acyltransferase Reactions. Mol Biol Cell 21(4):501-10
4) Schmidt C, et al.  (2013) Regulation of the yeast triacylglycerol lipase tgl3p by formation of nonpolar lipids. J Biol Chem 288(27):19939-48