Standard Name	NIP1 1
Systematic Name	YMR309C
Feature Type	ORF, Verified
Description	eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection (1, 2)
Name Description	Nuclear ImPort 1

Chromosomal Location	ChrXIII:895426 to 892988 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for NIP1
Molecular Function
Manually curated	translation initiation factor activity (IDA)
Biological Process
Manually curated	translational initiation (IDA, IGI, IMP)
Cellular Component
Manually curated	cytoplasm (IDA) cytoplasmic stress granule (IDA) eukaryotic translation initiation factor 3 complex (IDA, IPI) multi-eIF complex (IDA)
High-throughput	cytoplasm (IDA)

Classical genetics
conditional	heat sensitivity: increased resistance to paromomycin: decreased
repressible	polysome accumulation: decreased
Large-scale survey
null	competitive fitness: decreased haploinsufficient inviable starvation resistance: decreased
reduction of function	competitive fitness: increased resistance to methyl methanesulfonate: decreased resistance to benomyl: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	211 total interaction(s) for 84 unique genes/features.
Physical Interactions	Affinity Capture-MS: 120 Affinity Capture-RNA: 1 Affinity Capture-Western: 36 Biochemical Activity: 1 Co-fractionation: 3 Co-purification: 5 PCA: 1 Reconstituted Complex: 18 Two-hybrid: 16
Genetic Interactions	Dosage Rescue: 1 Phenotypic Suppression: 1 Synthetic Growth Defect: 5 Synthetic Lethality: 1 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:895426 to 892988 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2439 895426..892988 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004926