PSE1/YMR308C Summary Help

PSE1 BASIC INFORMATION

Standard Name PSE1
Systematic Name YMR308C
Alias KAP121
Feature Type ORF, Verified
Description Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p (1, 2, 3, 4, 5, 6)
Name Description Protein Secretion Enhancer
GO Annotations All PSE1 GO evidence and references
    View Computational GO annotations for PSE1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All PSE1 Phenotype details and references
Classical genetics
conditional
Large-scale survey
null
repressible
Interactions PSE1 All interactions details and references
197 total interaction(s) for 107 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 90
  • Affinity Capture-Western: 33
  • Co-fractionation: 1
  • Co-localization: 2
  • Co-purification: 1
  • FRET: 8
  • Protein-peptide: 2
  • Reconstituted Complex: 31
  • Two-hybrid: 23
Genetic Interactions
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 1
Sequence Information
ChrXIII:892220 to 888951 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2004-02-27 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..3270 892220..888951 2004-02-27 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004925

PSE1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Localization Resources
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for PSE1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PSE1]

1) Seedorf M and Silver PA  (1997) Importin/karyopherin protein family members required for mRNA export from the nucleus. Proc Natl Acad Sci U S A 94(16):8590-5
2) Marelli M, et al.  (1998) Specific binding of the karyopherin Kap121p to a subunit of the nuclear pore complex containing Nup53p, Nup59p, and Nup170p. J Cell Biol 143(7):1813-30
3) Isoyama T, et al.  (2001) Nuclear import of the yeast AP-1-like transcription factor Yap1p is mediated by transport receptor Pse1p, and this import step is not affected by oxidative stress. J Biol Chem 276(24):21863-9
4) Leslie DM, et al.  (2002) Kap121p-mediated nuclear import is required for mating and cellular differentiation in yeast. Mol Cell Biol 22(8):2544-55
5) Delahodde A, et al.  (2001) Pse1/Kap121-dependent nuclear localization of the major yeast multidrug resistance (MDR) transcription factor Pdr1. Mol Microbiol 39(2):304-12
6) Ueta R, et al.  (2003) Pse1p mediates the nuclear import of the iron-responsive transcription factor Aft1p in Saccharomyces cerevisiae. J Biol Chem 278(50):50120-7