UBP15/YMR304W Summary Help

Standard Name UBP15 1
Systematic Name YMR304W
Feature Type ORF, Verified
Description Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p (2, 3, 4)
Name Description UBiquitin-specific Protease 1
Chromosomal Location
ChrXIII:874987 to 878679 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All UBP15 GO evidence and references
  View Computational GO annotations for UBP15
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
unspecified
Resources
136 total interaction(s) for 115 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 61
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 4
  • Biochemical Activity: 8
  • Co-purification: 1
  • Protein-peptide: 2
  • Two-hybrid: 4

Genetic Interactions
  • Negative Genetic: 43
  • Positive Genetic: 6
  • Synthetic Growth Defect: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,230
Molecular Weight (Da) 143,563
Isoelectric Point (pI) 4.77
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:874987 to 878679 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3693 874987..878679 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004920
References cited on this page View Complete Literature Guide for UBP15
1) Amerik AY, et al.  (2000) Analysis of the deubiquitinating enzymes of the yeast Saccharomyces cerevisiae. Biol Chem 381(9-10):981-92
2) Layfield R, et al.  (1999) Chemically synthesized ubiquitin extension proteins detect distinct catalytic capacities of deubiquitinating enzymes. Anal Biochem 274(1):40-9
3) Bozza WP and Zhuang Z  (2011) Biochemical characterization of a multidomain deubiquitinating enzyme Ubp15 and the regulatory role of its terminal domains. Biochemistry 50(29):6423-32
4) Debelyy MO, et al.  (2011) Ubp15p, a ubiquitin hydrolase associated with the peroxisomal export machinery. J Biol Chem 286(32):28223-34