Standard Name	UBP15 1
Systematic Name	YMR304W
Feature Type	ORF, Verified
Description	Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p (2, 3, 4)
Name Description	UBiquitin-specific Protease 1

Chromosomal Location	ChrXIII:874987 to 878679 | ORF Map | GBrowse

	View Computational GO annotations for UBP15
Molecular Function
Manually curated	ubiquitin-specific protease activity (IDA, IMP)
Biological Process
Manually curated	protein deubiquitination (IDA, IMP, ISA)
Cellular Component
Manually curated	peroxisome (IDA)
High-throughput	cytoplasm (IDA)

Classical genetics
null	tellurium atom accumulation: decreased cold sensitivity: increased heat sensitivity: increased oxidative stress resistance: decreased peroxisomal morphology: abnormal resistance to canavanine sulfate: decreased
Large-scale survey
null	UV resistance: decreased auxotrophy cell cycle progression in G1 phase: increased duration cell size: decreased competitive fitness: decreased haploinsufficient resistance to arsenite(3-): decreased resistance to amiodarone: decreased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to paromomycin: decreased resistance to sirolimus: decreased resistance to acetic acid: decreased resistance to 5-fluorouracil: decreased resistance to hydroxyurea: decreased resistance to quinine: decreased starvation resistance: decreased stress resistance: decreased utilization of phosphorus source: decreased vegetative growth: decreased rate viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	129 total interaction(s) for 111 unique genes/features.
Physical Interactions	Affinity Capture-MS: 59 Affinity Capture-RNA: 2 Affinity Capture-Western: 4 Biochemical Activity: 7 Protein-peptide: 2 Two-hybrid: 4
Genetic Interactions	Negative Genetic: 40 Positive Genetic: 6 Synthetic Growth Defect: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:874987 to 878679 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3693 874987..878679 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004920