HER2/YMR293C Summary Help

Standard Name HER2 1
Systematic Name YMR293C
Alias GEP6 2 , RRG6 3
Feature Type ORF, Verified
Description Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase (1, 2, 4, 5, 6, 7)
Name Description Hmg2p ER Remodeling 1
Chromosomal Location
ChrXIII:856793 to 855399 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All HER2 GO evidence and references
  View Computational GO annotations for HER2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Classical genetics
Large-scale survey
339 total interaction(s) for 302 unique genes/features.
Physical Interactions
  • Affinity Capture-Western: 1
  • PCA: 1

Genetic Interactions
  • Dosage Rescue: 3
  • Negative Genetic: 218
  • Positive Genetic: 103
  • Synthetic Growth Defect: 9
  • Synthetic Lethality: 4

Expression Summary
Length (a.a.) 464
Molecular Weight (Da) 50,918
Isoelectric Point (pI) 8.88
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXIII:856793 to 855399 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1395 856793..855399 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Retired NameLRC6
Primary SGDIDS000004907
References cited on this page View Complete Literature Guide for HER2
1) Federovitch CM, et al.  (2008) Genetic and structural analysis of Hmg2p-induced endoplasmic reticulum remodeling in Saccharomyces cerevisiae. Mol Biol Cell 19(10):4506-20
2) Osman C, et al.  (2009) The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria. J Cell Biol 184(4):583-96
3) Merz S and Westermann B  (2009) Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae. Genome Biol 10(9):R95
4) Giaever G, et al.  (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
5) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
6) Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54
7) Frechin M, et al.  (2009) Yeast mitochondrial Gln-tRNA(Gln) is generated by a GatFAB-mediated transamidation pathway involving Arc1p-controlled subcellular sorting of cytosolic GluRS. Genes Dev 23(9):1119-30