HSH155/YMR288W Summary

HSH155 BASIC INFORMATION

Standard Name	HSH155 1
Systematic Name	YMR288W
Feature Type	ORF, Verified
Description	U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155 (1, 2, 3)
Name Description	Human Sap Homolog 1

GO Annotations	All HSH155 GO evidence and references
	View Computational GO annotations for HSH155
Molecular Function
Manually curated	mRNA binding (IDA)
Biological Process
Manually curated	nuclear mRNA splicing, via spliceosome (IPI) spliceosome assembly (IPI, ISS)
Cellular Component
Manually curated	colocalizes_with U2 snRNP (IDA) U2 snRNP (IDA) U2-type prespliceosome (IDA)

Mutant Phenotype	All HSH155 Phenotype details and references
Large-scale survey
conditional	heat sensitivity: increased
null	inviable

Interactions	HSH155 All interactions details and references
	85 total interaction(s) for 49 unique genes/features.
Physical Interactions	Affinity Capture-MS: 75 Affinity Capture-Western: 1 Biochemical Activity: 3 Co-purification: 1 Two-hybrid: 5

Sequence Information

ChrXIII:845570 to 848485 | |

Last Update

Coordinates: 2004-02-27 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2916	845570..848485	2004-02-27	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004901

HSH155 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for HSH155

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HSH155]

1)	Pauling MH, et al. (2000) Functional Cus1p is found with Hsh155p in a multiprotein splicing factor associated with U2 snRNA. Mol Cell Biol 20(6):2176-85
2)	Stevens SW, et al. (2002) Composition and functional characterization of the yeast spliceosomal penta-snRNP. Mol Cell 9(1):31-44
3)	McPheeters DS and Muhlenkamp P (2003) Spatial organization of protein-RNA interactions in the branch site-3' splice site region during pre-mRNA splicing in yeast. Mol Cell Biol 23(12):4174-86

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