GPI12/YMR281W Summary Help

Standard Name GPI12 1
Systematic Name YMR281W
Feature Type ORF, Verified
Description ER membrane protein involved in the second step of GPI anchor assembly; the second step is the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp; GPI stands for glycosylphosphatidylinositol (1)
Name Description GlycosylPhosphatidylInositol anchor biosynthesis 1
Chromosomal Location
ChrXIII:832339 to 833253 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All GPI12 GO evidence and references
  View Computational GO annotations for GPI12
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
conditional
null
overexpression
reduction of function
repressible
Resources
8 total interaction(s) for 8 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Biochemical Activity: 1

Genetic Interactions
  • Negative Genetic: 4
  • Positive Genetic: 1
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 304
Molecular Weight (Da) 35,446
Isoelectric Point (pI) 9.65
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:832339 to 833253 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..915 832339..833253 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004894
References cited on this page View Complete Literature Guide for GPI12
1) Watanabe R, et al.  (1999) Mammalian PIG-L and its yeast homologue Gpi12p are N-acetylglucosaminylphosphatidylinositol de-N-acetylases essential in glycosylphosphatidylinositol biosynthesis. Biochem J 339 ( Pt 1)():185-92