Standard Name	FCP1 1
Systematic Name	YMR277W
Feature Type	ORF, Verified
Description	Carboxy-terminal domain (CTD) phosphatase; essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p); relocalizes to the cytosol in response to hypoxia (2, 3)
Name Description	tfiiF-associating component of Ctd Phosphatase 1

Chromosomal Location	ChrXIII:820256 to 822454 | ORF Map | GBrowse

	View Computational GO annotations for FCP1
Molecular Function
Manually curated	protein serine/threonine phosphatase activity (IDA, IMP)
Biological Process
Manually curated	dephosphorylation of RNA polymerase II C-terminal domain (IDA, IMP) regulation of transcription from RNA polymerase II promoter (IGI, IMP)
Cellular Component
Manually curated	cytosol (IDA) nucleus (IDA, IPI)

Classical genetics
overexpression	budding: abnormal cell cycle progression in G1 phase: abnormal
Large-scale survey
null	haploinsufficient inviable
overexpression	inviable
reduction of function	competitive fitness: normal telomere length: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	80 total interaction(s) for 64 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-RNA: 2 Affinity Capture-Western: 1 Biochemical Activity: 1 Co-crystal Structure: 2 Protein-peptide: 2 Reconstituted Complex: 4 Two-hybrid: 18
Genetic Interactions	Dosage Growth Defect: 3 Dosage Rescue: 7 Negative Genetic: 1 Phenotypic Enhancement: 1 Phenotypic Suppression: 2 Positive Genetic: 5 Synthetic Growth Defect: 15 Synthetic Lethality: 13
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:820256 to 822454 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2199 820256..822454 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004890