ZDS1/YMR273C Summary 
| Standard Name | ZDS1 1, 2 (see Nomenclature conflict Note) |
|---|---|
| Systematic Name | YMR273C |
| Alias | CES1 3 , CKM1 , NRC1 , OSS1 4 |
| Feature Type | ORF, Verified |
| Description | Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication (2, 5, 6, 7, 8, 9, 10, 11) |
| Name Description | Zillion Different Screens 1, 2 |
| Chromosomal Location | |
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| Note: this feature is encoded on the Crick strand. | |
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Gene Ontology Annotations All ZDS1 GO evidence and references
| View Computational GO annotations for ZDS1 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated |
Regulatory Role
| Regulatory modules | predicted: stressResponse (529) predicted: cellcycle (323) predicted: stressResponse (529) predicted: cellcycle (323) |
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Mutant phenotypes All ZDS1 Phenotype evidence and references
interactions All ZDS1 Interaction evidence and references
| 197 total interaction(s) for 121 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| Resources |
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Expression Summary
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| Resources |
Protein Information All ZDS1 Protein evidence and references
| Localization | |
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| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
sequence information
| Note: this feature is encoded on the Crick strand. | |||||||||||||
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| Last Update | Coordinates: 2011-02-03 | Sequence: 1996-07-31 | ||||||||||||
| Subfeature details |
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Analyze Sequence
| S288C only | |
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| S288C vs. other species | |
| S288C vs. other strains |
Resources
| External Links | All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
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| Primary SGDID | S000004886 |
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NOMENCLATURE CONFLICT NOTE
| Name | Relevance | Description |
|---|---|---|
| OSS1 | Nomenclature conflict | OSS1 has been used in the literature to refer to both ZDS1/YMR273C, which encodes a protein involved in transcriptional silencing and polarity establishment, and OSS1, a genetically defined locus on the mitochondrial chromosome that confers ossamycin resistance when mutated. |
References cited on this page View Complete Literature Guide for ZDS1
| 1) | Yu Y, et al. (1996) Mutations in the homologous ZDS1 and ZDS2 genes affect cell cycle progression. Mol Cell Biol 16(10):5254-63 |
| 2) | Bi E and Pringle JR (1996) ZDS1 and ZDS2, genes whose products may regulate Cdc42p in Saccharomyces cerevisiae. Mol Cell Biol 16(10):5264-75 |
| 3) | Schwer B and Shuman S (1996) Multicopy suppressors of temperature-sensitive mutations of yeast mRNA capping enzyme. Gene Expr 5(6):331-44 |
| 4) | Ma XJ, et al. (1996) A search for proteins that interact genetically with histone H3 and H4 amino termini uncovers novel regulators of the Swe1 kinase in Saccharomyces cerevisiae. Genes Dev 10(11):1327-40 |
| 5) | Roy N and Runge KW (1999) The ZDS1 and ZDS2 proteins require the Sir3p component of yeast silent chromatin to enhance the stability of short linear centromeric plasmids. Chromosoma 108(3):146-61 |
| 6) | Griffioen G, et al. (2001) Nucleocytoplasmic distribution of budding yeast protein kinase A regulatory subunit Bcy1 requires Zds1 and is regulated by Yak1-dependent phosphorylation of its targeting domain. Mol Cell Biol 21(2):511-23 |
| 7) | Estruch F, et al. (2005) Physical and genetic interactions link the yeast protein Zds1p with mRNA nuclear export. J Biol Chem 280(10):9691-7 |
| 8) | Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 |
| 9) | Queralt E and Uhlmann F (2008) Separase cooperates with Zds1 and Zds2 to activate Cdc14 phosphatase in early anaphase. J Cell Biol 182(5):873-83 |
| 10) | Yasutis K, et al. (2010) Zds2p Regulates Swe1p-dependent Polarized Cell Growth in Saccharomyces cerevisiae via a Novel Cdc55p Interaction Domain. Mol Biol Cell 21(24):4373-86 |
| 11) | Rossio V and Yoshida S (2011) Spatial regulation of Cdc55-PP2A by Zds1/Zds2 controls mitotic entry and mitotic exit in budding yeast. J Cell Biol 193(3):445-54 |
