ZDS1/YMR273C Summary Help

Standard Name ZDS1 1, 2
Systematic Name YMR273C
Alias CES1 3 , CKM1 , NRC1 , OSS1 4
Feature Type ORF, Verified
Description Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication (2, 5, 6, 7, 8, 9, 10, 11)
Name Description Zillion Different Screens 1, 2
Chromosomal Location
ChrXIII:813980 to 811233 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All ZDS1 GO evidence and references
  View Computational GO annotations for ZDS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Classical genetics
Large-scale survey
200 total interaction(s) for 120 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 37
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 9
  • Biochemical Activity: 2
  • Reconstituted Complex: 2
  • Two-hybrid: 12

Genetic Interactions
  • Dosage Lethality: 4
  • Dosage Rescue: 23
  • Negative Genetic: 48
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 15
  • Positive Genetic: 20
  • Synthetic Growth Defect: 9
  • Synthetic Lethality: 3
  • Synthetic Rescue: 7

Expression Summary
Length (a.a.) 915
Molecular Weight (Da) 103,358
Isoelectric Point (pI) 6.32
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXIII:813980 to 811233 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..2748 813980..811233 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004886
References cited on this page View Complete Literature Guide for ZDS1
1) Yu Y, et al.  (1996) Mutations in the homologous ZDS1 and ZDS2 genes affect cell cycle progression. Mol Cell Biol 16(10):5254-63
2) Bi E and Pringle JR  (1996) ZDS1 and ZDS2, genes whose products may regulate Cdc42p in Saccharomyces cerevisiae. Mol Cell Biol 16(10):5264-75
3) Schwer B and Shuman S  (1996) Multicopy suppressors of temperature-sensitive mutations of yeast mRNA capping enzyme. Gene Expr 5(6):331-44
4) Ma XJ, et al.  (1996) A search for proteins that interact genetically with histone H3 and H4 amino termini uncovers novel regulators of the Swe1 kinase in Saccharomyces cerevisiae. Genes Dev 10(11):1327-40
5) Roy N and Runge KW  (1999) The ZDS1 and ZDS2 proteins require the Sir3p component of yeast silent chromatin to enhance the stability of short linear centromeric plasmids. Chromosoma 108(3):146-61
6) Griffioen G, et al.  (2001) Nucleocytoplasmic distribution of budding yeast protein kinase A regulatory subunit Bcy1 requires Zds1 and is regulated by Yak1-dependent phosphorylation of its targeting domain. Mol Cell Biol 21(2):511-23
7) Estruch F, et al.  (2005) Physical and genetic interactions link the yeast protein Zds1p with mRNA nuclear export. J Biol Chem 280(10):9691-7
8) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
9) Queralt E and Uhlmann F  (2008) Separase cooperates with Zds1 and Zds2 to activate Cdc14 phosphatase in early anaphase. J Cell Biol 182(5):873-83
10) Yasutis K, et al.  (2010) Zds2p Regulates Swe1p-dependent Polarized Cell Growth in Saccharomyces cerevisiae via a Novel Cdc55p Interaction Domain. Mol Biol Cell 21(24):4373-86
11) Rossio V and Yoshida S  (2011) Spatial regulation of Cdc55-PP2A by Zds1/Zds2 controls mitotic entry and mitotic exit in budding yeast. J Cell Biol 193(3):445-54