Standard Name	PPA2 1
Systematic Name	YMR267W
Alias	IPP2
Feature Type	ORF, Verified
Description	Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate (2, 3, 4)
Name Description	PyroPhosphatAse 2

Chromosomal Location	ChrXIII:801772 to 802704 | ORF Map | GBrowse

	View Computational GO annotations for PPA2
Molecular Function
Manually curated	inorganic diphosphatase activity (IMP, ISS)
Biological Process
Manually curated	aerobic respiration (IMP)
Cellular Component
Manually curated	mitochondrion (IMP)
High-throughput	mitochondrion (IDA)

Classical genetics
null	chromosome/plasmid maintenance: abnormal resistance to benomyl: decreased
Large-scale survey
null	glycogen accumulation: decreased competitive fitness: decreased dessication resistance: decreased heat sensitivity: increased mitochondrial morphology: abnormal resistance to 2,4-dichlorophenol: decreased resistance to 2,4-Diacetylphloroglucinol: decreased resistance to trichothecene: increased resistance to paromomycin: decreased resistance to cycloheximide: decreased resistance to ethanol: decreased respiratory growth: absent respiratory growth: decreased rate stress resistance: increased toxin resistance: increased utilization of carbon source: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	393 total interaction(s) for 347 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 1 Two-hybrid: 5
Genetic Interactions	Negative Genetic: 196 Phenotypic Enhancement: 1 Positive Genetic: 179 Synthetic Growth Defect: 3 Synthetic Lethality: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:801772 to 802704 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..933 801772..802704 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004880