SAP30/YMR263W Summary Help

Standard Name SAP30
Systematic Name YMR263W
Feature Type ORF, Verified
Description Component of Rpd3L histone deacetylase complex; involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance (1, 2, 3, 4, 5)
Name Description SIT4 protein phosphatase Associated Protein
Chromosomal Location
ChrXIII:794919 to 795524 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SAP30 GO evidence and references
  View Computational GO annotations for SAP30
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
repressible
Resources
669 total interaction(s) for 343 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 62
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 9
  • Reconstituted Complex: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 343
  • Positive Genetic: 77
  • Synthetic Growth Defect: 116
  • Synthetic Lethality: 43
  • Synthetic Rescue: 11

Resources
Expression Summary
histogram
Resources
Length (a.a.) 201
Molecular Weight (Da) 23,026
Isoelectric Point (pI) 10.53
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:794919 to 795524 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..606 794919..795524 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004876
References cited on this page View Complete Literature Guide for SAP30
1) Sun ZW and Hampsey M  (1999) A general requirement for the Sin3-Rpd3 histone deacetylase complex in regulating silencing in Saccharomyces cerevisiae. Genetics 152(3):921-32
2) Zhang Y, et al.  (1998) SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Mol Cell 1(7):1021-31
3) Bernstein BE, et al.  (2000) Genomewide studies of histone deacetylase function in yeast. Proc Natl Acad Sci U S A 97(25):13708-13
4) Carrozza MJ, et al.  (2005) Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex. Biochim Biophys Acta 1731(2):77-87; discussion 75-6
5) Askree SH, et al.  (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63