Standard Name	SAP30
Systematic Name	YMR263W
Feature Type	ORF, Verified
Description	Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance (1, 2, 3, 4)
Name Description	SIT4 protein phosphatase Associated Protein

Chromosomal Location	ChrXIII:794919 to 795524 | ORF Map | GBrowse

	View Computational GO annotations for SAP30
Molecular Function
Manually curated	histone deacetylase activity (IPI)
Biological Process
Manually curated	negative regulation of chromatin silencing at rDNA (IMP) negative regulation of chromatin silencing at silent mating-type cassette (IMP) negative regulation of chromatin silencing at telomere (IMP) negative regulation of transcription from RNA polymerase I promoter (IMP) positive regulation of transcription from RNA polymerase II promoter (IMP) positive regulation of transcription from RNA polymerase II promoter in response to heat stress (IMP)
Cellular Component
Manually curated	histone deacetylase complex (IPI) Rpd3L complex (IDA)
High-throughput	Rpd3L complex (IDA) Rpd3L-Expanded complex (IDA)

Classical genetics
null	inositol excretion: increased chronological lifespan: decreased mating efficiency: decreased resistance to acetic acid: decreased resistance to bortezomib: decreased
Large-scale survey
null	UV resistance: decreased acid pH resistance: decreased glycogen accumulation: decreased competitive fitness: decreased dessication resistance: decreased endocytosis: decreased haploinsufficient resistance to bleomycin: increased resistance to caffeine: increased resistance to methyl methanesulfonate: increased resistance to sulfanilamide: decreased resistance to sulfometuron methyl: decreased resistance to sodium arsenite: decreased resistance to propolis extract: decreased resistance to cycloheximide: decreased resistance to tunicamycin: decreased resistance to doxorubicin: decreased respiratory growth: decreased rate stress resistance: decreased telomere length: decreased vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	667 total interaction(s) for 343 unique genes/features.
Physical Interactions	Affinity Capture-MS: 62 Affinity Capture-RNA: 4 Affinity Capture-Western: 9 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 342 Positive Genetic: 77 Synthetic Growth Defect: 115 Synthetic Lethality: 43 Synthetic Rescue: 11
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:794919 to 795524 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..606 794919..795524 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004876