FAA4/YMR246W Summary

FAA4 BASIC INFORMATION

Standard Name	FAA4
Systematic Name	YMR246W
Feature Type	ORF, Verified
Description	Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids (1, 2)
Name Description	Fatty Acid Activation

GO Annotations	All FAA4 GO evidence and references
	View Computational GO annotations for FAA4
Molecular Function
Manually curated	long-chain-fatty-acid-CoA ligase activity (IDA)
Biological Process
Manually curated	cellular lipid metabolic process (IGI, IMP) lipid transport (IGI, IPI) long-chain fatty acid metabolic process (IGI) long-chain fatty acid transport (IGI) N-terminal protein myristoylation (IGI, IMP)
Cellular Component
Manually curated	lipid particle (IDA)
High-throughput	cytoplasm (IDA)

Pathways	fatty acid oxidation pathway

Mutant Phenotype	All FAA4 Phenotype details and references
Classical genetics
null	oleoyl-CoA accumulation: decreased acyl-CoA accumulation: abnormal resistance to cerulenin: normal
Large-scale survey
null	resistance to amiodarone: decreased viable
overexpression	vegetative growth: decreased

Interactions	FAA4 All interactions details and references
	32 total interaction(s) for 23 unique genes/features.
Physical Interactions	Affinity Capture-MS: 19 Affinity Capture-Western: 2 Co-fractionation: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 2 Phenotypic Enhancement: 1 Synthetic Growth Defect: 3 Synthetic Lethality: 3

Sequence Information

ChrXIII:759806 to 761890 | |

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2085	759806..761890	1996-07-31	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004860

FAA4 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for FAA4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for FAA4]

1)	Johnson DR, et al. (1994) Saccharomyces cerevisiae contains four fatty acid activation (FAA) genes: an assessment of their role in regulating protein N-myristoylation and cellular lipid metabolism. J Cell Biol 127(3):751-62
2)	Nozawa M, et al. (2002) A role of Saccharomyces cerevisiae fatty Acid activation protein 4 in palmitoyl-CoA pool for growth in the presence of ethanol. J Biosci Bioeng 93(3):288-95

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