ZRC1/YMR243C Summary Help

Standard Name ZRC1 (see Nomenclature conflict Note)
Systematic Name YMR243C
Alias OSR1
Feature Type ORF, Verified
Description Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description Zinc Resistance Conferring 6
Chromosomal Location
ChrXIII:756166 to 754838 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All ZRC1 GO evidence and references
  View Computational GO annotations for ZRC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant phenotypes All ZRC1 Phenotype evidence and references
Classical genetics
null
Large-scale survey
null
overexpression
Resources
interactions All ZRC1 Interaction evidence and references
72 total interaction(s) for 50 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-Western: 1
  • PCA: 6
  • Two-hybrid: 3
Genetic Interactions
  • Dosage Rescue: 5
  • Negative Genetic: 46
  • Phenotypic Enhancement: 2
  • Positive Genetic: 2
  • Synthetic Growth Defect: 4
Resources
Expression Summary
histogram
Resources
Protein Information All ZRC1 Protein evidence and references
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:756166 to 754838 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1329 756166..754838 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000004856

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
PBS2Nomenclature conflictOSR1 has been used in the literature to refer to both PBS2/YJL128C, which encodes a MAP kinase kinase, and ZRC1/YMR243C, which encodes a vacuolar zinc transporter.
References cited on this page View Complete Literature Guide for ZRC1
1) MacDiarmid CW, et al.  (2000) Zinc transporters that regulate vacuolar zinc storage in Saccharomyces cerevisiae. EMBO J 19(12):2845-55
2) Li L and Kaplan J  (1998) Defects in the yeast high affinity iron transport system result in increased metal sensitivity because of the increased expression of transporters with a broad transition metal specificity. J Biol Chem 273(35):22181-7
3) MacDiarmid CW, et al.  (2003) Induction of the ZRC1 metal tolerance gene in zinc-limited yeast confers resistance to zinc shock. J Biol Chem 278(17):15065-72
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Tuschl K, et al.  (2012) Syndrome of hepatic cirrhosis, dystonia, polycythemia, and hypermanganesemia caused by mutations in SLC30A10, a manganese transporter in man. Am J Hum Genet 90(3):457-66
6) Kamizono A, et al.  (1989) Identification of a gene conferring resistance to zinc and cadmium ions in the yeast Saccharomyces cerevisiae. Mol Gen Genet 219(1-2):161-7