Standard Name	YHM2 1
Systematic Name	YMR241W
Feature Type	ORF, Verified
Description	Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome (1, 2, 3)
Name Description	Yeast suppressor of HM mutant 1

Chromosomal Location	ChrXIII:751961 to 752905 | ORF Map | GBrowse

	View Computational GO annotations for YHM2
Molecular Function
Manually curated	DNA binding (IDA) tricarboxylate secondary active transmembrane transporter activity (IDA)
Biological Process
Manually curated	alpha-ketoglutarate transport (IDA) mitochondrial citrate transport (IDA) mitochondrial genome maintenance (IGI, IMP) tricarboxylic acid transport (IDA)
Cellular Component
Manually curated	mitochondrial inner membrane (ISS) mitochondrial nucleoid (IDA) mitochondrion (IDA)
High-throughput	integral to membrane (ISM) mitochondrion (IDA)

Classical genetics
null	citric acid accumulation: abnormal resistance to hydrogen peroxide: decreased utilization of carbon source: decreased
Large-scale survey
null	competitive fitness: decreased haploinsufficient starvation resistance: decreased stress resistance: increased viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	90 total interaction(s) for 77 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-RNA: 3 Biochemical Activity: 3 PCA: 1
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 45 Positive Genetic: 19 Synthetic Growth Defect: 3 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:751961 to 752905 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..945 751961..752905 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB

Primary SGDID	S000004854