YHM2/YMR241W Summary Help

Standard Name YHM2 1
Systematic Name YMR241W
Feature Type ORF, Verified
Description Citrate and oxoglutarate carrier protein; exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome (1, 2, 3)
Name Description Yeast suppressor of HM mutant 1
Chromosomal Location
ChrXIII:751961 to 752905 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All YHM2 GO evidence and references
  View Computational GO annotations for YHM2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
94 total interaction(s) for 80 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 16
  • Affinity Capture-RNA: 4
  • Biochemical Activity: 3
  • PCA: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 45
  • Positive Genetic: 19
  • Synthetic Growth Defect: 3
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 314
Molecular Weight (Da) 34,184
Isoelectric Point (pI) 10.68
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:751961 to 752905 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..945 751961..752905 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000004854
References cited on this page View Complete Literature Guide for YHM2
1) Cho JH, et al.  (1998) A novel DNA-binding protein bound to the mitochondrial inner membrane restores the null mutation of mitochondrial histone Abf2p in Saccharomyces cerevisiae. Mol Cell Biol 18(10):5712-23
2) Mayor JA, et al.  (1997) Bacterial overexpression of putative yeast mitochondrial transport proteins. J Bioenerg Biomembr 29(6):541-7
3) Castegna A, et al.  (2010) Identification and functional characterization of a novel mitochondrial carrier for citrate and oxoglutarate in Saccharomyces cerevisiae. J Biol Chem 285(23):17359-70