CUS1/YMR240C Summary

CUS1 BASIC INFORMATION

Standard Name	CUS1
Systematic Name	YMR240C
Feature Type	ORF, Verified
Description	Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p (1)
Name Description	Cold sensitive U2 snRNA Suppressor 2

GO Annotations	All CUS1 GO evidence and references
	View Computational GO annotations for CUS1
Molecular Function
Manually curated	protein binding (IDA) RNA binding (IDA)
Biological Process
Manually curated	nuclear mRNA splicing, via spliceosome (IPI) spliceosome assembly (IDA)
Cellular Component
Manually curated	colocalizes_with U2 snRNP (IDA) U2 snRNP (IDA) U2-type prespliceosome (IDA)

Mutant Phenotype	All CUS1 Phenotype details and references
Large-scale survey
null	inviable

Interactions	CUS1 All interactions details and references
	115 total interaction(s) for 53 unique genes/features.
Physical Interactions	Affinity Capture-MS: 90 Affinity Capture-Western: 2 Co-purification: 1 Reconstituted Complex: 1 Two-hybrid: 14
Genetic Interactions	Dosage Rescue: 2 Phenotypic Enhancement: 2 Phenotypic Suppression: 2 Synthetic Rescue: 1

Sequence Information

ChrXIII:751239 to 749929 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1311	751239..749929	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004853

CUS1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CUS1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CUS1]

1)	Pauling MH, et al. (2000) Functional Cus1p is found with Hsh155p in a multiprotein splicing factor associated with U2 snRNA. Mol Cell Biol 20(6):2176-85
2)	Wells SE, et al. (1996) CUS1, a suppressor of cold-sensitive U2 snRNA mutations, is a novel yeast splicing factor homologous to human SAP 145. Genes Dev 10(2):220-32

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